Tchem TERT Telomerase reverse transcriptase

Protein Summary

Description

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14746
• O14783
• Q2XS35
• Q8N6C3
• Q8NG38
• Q8NG46

Gene Name

• TERT

Ensembl ID

• ENST00000310581
• ENSP00000309572
• ENSG00000164362
• ENST00000334602
• ENSP00000334346
• ENST00000460137
• ENSP00000425003

Symbol

• EST2
• TCS1
• TRT
• TP2
• TRT
• CMM9
• EST2
• TCS1
• hTRT
• DKCA2
• DKCB4
• hEST2
• PFBMFT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.97
biological process	0.96
cellular component	0.95
hub protein	0.94
molecular function	0.94

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Reverse Transcriptase / Telomerase Reverse Transcriptase

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Reverse Transcriptase / Telomerase Reverse Transcriptase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4839.56   (req: < 5)

Gene RIFs: 1944   (req: <= 3)

Antibodies: 909   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4839.56   (req: >= 5)

Gene RIFs: 1944   (req: > 3)

Antibodies: 909   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 171

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0