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Tchem
TERF2
Telomeric repeat-binding factor 2

Protein Summary
Description
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254942
  • ENSP00000254942
  • ENSG00000132604
  • ENST00000567296
  • ENSP00000454955

Symbol
  • TRBF2
  • TRF2
  • TRF2
  • TRBF2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
biological process
0.93
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.8
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.05   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 523   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.05   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 523   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (124)
DCLRE1B
Tbio
Family:  Enzyme
Novelty:  0.0598925
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
TADA2B
Tbio
Family:  TF
Novelty:  0.06387677
p_int:  0.999999902
p_ni:  9.8e-8
p_wrong:  1e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
TINF2
Tbio
Novelty:  0.0064505
p_int:  0.999995901
p_ni:  0.000004099
Score:  0.999
Data Source:  BioPlex,STRINGDB
ARL4D
Tbio
Family:  Enzyme
Novelty:  0.13254344
p_int:  0.99999495
p_ni:  0.00000505
Score:  0.243
Data Source:  BioPlex,STRINGDB
XAGE1A
Tbio
Novelty:  0.04421526
p_int:  0.999989044
p_ni:  0.000010951
p_wrong:  5e-9
Data Source:  BioPlex
POT1
Tbio
Novelty:  0.01042607
p_int:  0.999981015
p_ni:  0.00001898
p_wrong:  5e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
PRPF40A
Tbio
Novelty:  0.00898047
p_int:  0.999957368
p_ni:  0.000042632
Score:  0.21
Data Source:  BioPlex,STRINGDB
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.999689782
p_ni:  0.000310209
p_wrong:  9e-9
Score:  0.176
Data Source:  BioPlex,STRINGDB
CCDC106
Tdark
Novelty:  0.7081207
p_int:  0.999200797
p_ni:  0.000799195
p_wrong:  8e-9
Score:  0.234
Data Source:  BioPlex,STRINGDB
FGFRL1
Tbio
Novelty:  0.02178846
p_int:  0.998520664
p_ni:  0.001478231
p_wrong:  0.000001105
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (143)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cell Cycle
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cell Cycle
Cellular Senescence
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (43)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence Model (ISM)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
2
4
80.6
daytime rest measurement
1
1
1
55.2
telomere length
1
1
1
38.8
apolipoprotein A 1 measurement
1
1
1
35
total cholesterol measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
80.6
daytime rest measurement
1
55.2
telomere length
1
38.8
apolipoprotein A 1 measurement
1
35
total cholesterol measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
telomeric repeat binding factor 2
VGNC:5932
454201
Macaque
telomeric repeat binding factor 2
704879
Mouse
MGI:1195972
21750
Rat
RGD:1310881
361403
Dog
telomeric repeat binding factor 2
VGNC:49661
489736
Species
Name
OMA
EggNOG
Inparanoid
Chimp
telomeric repeat binding factor 2
Macaque
telomeric repeat binding factor 2
Mouse
Rat
Dog
telomeric repeat binding factor 2
Publication Statistics
PubMed Score 106.05
PubMed score by year
PubTator Score 338.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title