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Tbio
TERF1
Telomeric repeat-binding factor 1

Protein Summary
Description
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are al ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276602
  • ENSP00000276602
  • ENSG00000147601
  • ENST00000276603
  • ENSP00000276603

Symbol
  • PIN2
  • TRBF1
  • TRF
  • TRF1
  • TRF
  • PIN2
  • TRF1
  • TRBF1
  • t-TRF1
  • hTRF1-AS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
virus perturbation
0.92
transcription factor perturbation
0.84
kinase
0.8
biological process
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 626.29   (req: < 5)
Gene RIFs: 87   (req: <= 3)
Antibodies: 621   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 626.29   (req: >= 5)
Gene RIFs: 87   (req: > 3)
Antibodies: 621   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (174)
TINF2
Tbio
Novelty:  0.0064505
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
POT1
Tbio
Novelty:  0.01042607
p_int:  0.999999999
p_ni:  1e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
PINX1
Tbio
Family:  TF
Novelty:  0.01237398
p_int:  0.999999951
p_ni:  4.6e-8
p_wrong:  3e-9
Score:  0.898
Data Source:  BioPlex,STRINGDB
ACD
Tbio
Novelty:  0.00517732
p_int:  0.999998242
p_ni:  0.000001758
Score:  0.997
Data Source:  BioPlex,STRINGDB
TNKS
Tchem
Family:  Enzyme
Novelty:  0.00404545
p_int:  0.99888447
p_ni:  0.00111553
Score:  0.994
Data Source:  BioPlex,STRINGDB
TNKS2
Tchem
Family:  Enzyme
Novelty:  0.00938509
p_int:  0.998034765
p_ni:  0.001965235
Score:  0.868
Data Source:  BioPlex,STRINGDB
NAGK
Tbio
Family:  Kinase
Novelty:  0.01603908
p_int:  0.960606734
p_ni:  0.000389305
p_wrong:  0.039003961
Data Source:  BioPlex
DCLRE1B
Tbio
Family:  Enzyme
Novelty:  0.0598925
Score:  0.988
Data Source:  STRINGDB
TERF2IP
Tchem
Novelty:  0.06285957
Score:  0.984
Data Source:  STRINGDB
TERT
Tchem
Family:  Enzyme
Novelty:  0.00024411
Score:  0.983
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cell Cycle
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cell Cycle
Cellular Senescence
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (48)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence Model (ISM)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
2
2
2
67.9
1
1
0
1.1
21.5
age at first sexual intercourse measurement
1
1
1
5.1
insomnia measurement
1
1
0
1
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
2
67.9
0
1.1
21.5
age at first sexual intercourse measurement
1
5.1
insomnia measurement
0
1
0.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
telomeric repeat binding factor 1
VGNC:8184
745755
Macaque
telomeric repeat binding factor 1
695119
Mouse
MGI:109634
21749
Rat
RGD:1311574
297758
Dog
telomeric repeat binding factor 1
VGNC:47254
100684790
Species
Name
OMA
EggNOG
Inparanoid
Chimp
telomeric repeat binding factor 1
Macaque
telomeric repeat binding factor 1
Mouse
Rat
Dog
telomeric repeat binding factor 1
Publication Statistics
PubMed Score 626.29
PubMed score by year
PubTator Score 395.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title