Pharos : Target Details

Tdark

Protein Summary

Description

Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA.

Uniprot Accession IDs

Q8NHR7

Gene Name

TERB2

Ensembl ID

ENST00000340827
ENSP00000340644
ENSG00000167014

Symbol

C15orf43
C15orf43

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0

biological term	0

cell line	0

cell type or tissue	0

cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.8 (req: < 5)

View Publications

Gene RIFs: 1 (req: <= 3)

View Gene RIFs

Antibodies: 6 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.8 (req: >= 5)

Gene RIFs: 1 (req: > 3)

Antibodies: 6 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (20)

Explore Interacting Targets

1 – 10 of 20

See Interactions on String-DB

RIBC1

Tdark

Novelty: 0.40435429

Score: 0.802

Data Source: STRINGDB

MAJIN

Tdark

Novelty: 0.24903194

Score: 0.774

Data Source: STRINGDB

C1orf43

Tbio

Novelty: 0.13587458

Score: 0.724

Data Source: STRINGDB

CABP2

Tbio

Novelty: 0.08451877

Score: 0.695

Data Source: STRINGDB

TERB1

Tdark

Family: TF

Novelty: 0.20863595

Score: 0.676

Data Source: STRINGDB

OR2T5

Tdark

Family: oGPCR

Novelty: 8.29770176

Score: 0.675

Data Source: STRINGDB

QSER1

Tdark

Novelty: 0.62017582

Score: 0.56

Data Source: STRINGDB

KRTAP21-1

Tdark

Novelty: 3.10605405

Score: 0.554

Data Source: STRINGDB

PCDHA13

Tdark

Novelty: 1.14537708

Score: 0.552

Data Source: STRINGDB

PRIMA1

Tbio

Novelty: 0.01886606

Score: 0.548

Data Source: STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Components (2)

Processes (3)

Find Similar Targets

Items per page:

1 – 2 of 2

GO Term	Evidence	Assigned by
nuclear chromosome, telomeric region	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

nuclear inner membrane	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (2)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
creatinine measurement	EFO_0004518	1	1	1	38.8

glomerular filtration rate	EFO_0005208	1	1	1	35

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
creatinine measurement	EFO_0004518	1	38.8

glomerular filtration rate	EFO_0005208	1	35

Beta Count

Odds Ratio

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UniProt Keyword

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GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID
Chimp	telomere repeat binding bouquet formation protein 2	VGNC:3577	743640

Mouse	telomere repeat binding bouquet formation protein 2	MGI:1921651	74401

Rat	telomere repeat binding bouquet formation protein 2	RGD:1593334	691952

Dog	telomere repeat binding bouquet formation protein 2	VGNC:47253	478286

Horse	telomere repeat binding bouquet formation protein 2	VGNC:24002	100070595

Species	Name	OMA	EggNOG	Inparanoid
Chimp	telomere repeat binding bouquet formation protein 2

Mouse	telomere repeat binding bouquet formation protein 2

Rat	telomere repeat binding bouquet formation protein 2

Dog	telomere repeat binding bouquet formation protein 2

Horse	telomere repeat binding bouquet formation protein 2

Publication Statistics

PubMed Score 2.80

PubMed score by year

PubTator Score 0.13

PubTator score by year

Related Publications

Text Mined References (4)

GeneRif Annotations (1)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
Chromosome

Complete proteome

Membrane

Nucleus

Polymorphism

Reference proteome

Telomere