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Tdark
TERB2
Telomere repeats-binding bouquet formation protein 2

Protein Summary
Description
Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340827
  • ENSP00000340644
  • ENSG00000167014

Symbol
  • C15orf43
  • C15orf43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.8   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 6   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.8   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
RIBC1
Tdark
Novelty:  0.40435429
Score:  0.802
Data Source:  STRINGDB
MAJIN
Tdark
Novelty:  0.24903194
Score:  0.774
Data Source:  STRINGDB
C1orf43
Tbio
Novelty:  0.13587458
Score:  0.724
Data Source:  STRINGDB
CABP2
Tbio
Novelty:  0.08451877
Score:  0.695
Data Source:  STRINGDB
TERB1
Tdark
Family:  TF
Novelty:  0.20863595
Score:  0.676
Data Source:  STRINGDB
OR2T5
Tdark
Family:  oGPCR
Novelty:  8.29770176
Score:  0.675
Data Source:  STRINGDB
QSER1
Tdark
Novelty:  0.62017582
Score:  0.56
Data Source:  STRINGDB
KRTAP21-1
Tdark
Novelty:  3.10605405
Score:  0.554
Data Source:  STRINGDB
PCDHA13
Tdark
Novelty:  1.14537708
Score:  0.552
Data Source:  STRINGDB
PRIMA1
Tbio
Novelty:  0.01886606
Score:  0.548
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
1
1
38.8
glomerular filtration rate
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
38.8
glomerular filtration rate
1
35
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
telomere repeat binding bouquet formation protein 2
VGNC:3577
743640
Mouse
MGI:1921651
74401
Rat
RGD:1593334
691952
Dog
telomere repeat binding bouquet formation protein 2
VGNC:47253
478286
Horse
telomere repeat binding bouquet formation protein 2
VGNC:24002
100070595
Species
Name
OMA
EggNOG
Inparanoid
Chimp
telomere repeat binding bouquet formation protein 2
Mouse
Rat
Dog
telomere repeat binding bouquet formation protein 2
Horse
telomere repeat binding bouquet formation protein 2
Publication Statistics
PubMed Score 2.80
PubMed score by year
PubTator Score 0.13
PubTator score by year
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Related Publications
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PMID
Year
Title