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Tbio
TEP1
Telomerase protein component 1

Protein Summary
Description
Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (PubMed:19179534). Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport (By similarity). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity). This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262715
  • ENSP00000262715
  • ENSG00000129566

Symbol
  • TLP1
  • TP1
  • TP1
  • TLP1
  • p240
  • TROVE1
  • VAULT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.93
histone modification site profile
0.87
cell type or tissue
0.86
cell line
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.19   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.19   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (123)
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
p_int:  0.99999858
p_ni:  0.00000136
p_wrong:  6e-8
Score:  0.203
Data Source:  BioPlex,STRINGDB
TIRAP
Tbio
Novelty:  0.00600495
p_int:  0.999301433
p_ni:  6.51e-7
p_wrong:  0.000697916
Score:  0.511
Data Source:  BioPlex,STRINGDB
TERT
Tchem
Family:  Enzyme
Novelty:  0.00024411
Score:  0.978
Data Source:  STRINGDB
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
Score:  0.941
Data Source:  STRINGDB
DKC1
Tbio
Novelty:  0.00352181
Score:  0.939
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.938
Data Source:  STRINGDB
TNKS
Tchem
Family:  Enzyme
Novelty:  0.00404545
Score:  0.938
Data Source:  STRINGDB
WRAP53
Tbio
Family:  Enzyme
Novelty:  0.0204638
Score:  0.915
Data Source:  STRINGDB
NVL
Tbio
Family:  Enzyme
Novelty:  0.15855985
Score:  0.908
Data Source:  STRINGDB
PPP2R5D
Tbio
Family:  Enzyme
Novelty:  0.03990599
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
1
1
1
73.6
metabolite measurement
1
1
1
65.6
aspartate aminotransferase measurement
2
1
1
6.8
62.1
1
1
0
1.6
27.3
serum alanine aminotransferase measurement
1
1
0
5.6
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
1
73.6
metabolite measurement
1
65.6
aspartate aminotransferase measurement
1
6.8
62.1
0
1.6
27.3
serum alanine aminotransferase measurement
0
5.6
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:109573
21745
Rat
RGD:3869
64523
Dog
telomerase associated protein 1
VGNC:47249
482555
Horse
telomerase associated protein 1
VGNC:24000
100072576
Cow
telomerase associated protein 1
VGNC:35745
505802
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
telomerase associated protein 1
Horse
telomerase associated protein 1
Cow
telomerase associated protein 1
Publication Statistics
PubMed Score 82.19
PubMed score by year
PubTator Score 151.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title