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Tbio
TENM3
Teneurin-3

Protein Summary
Description
Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microph ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000511685
  • ENSP00000424226
  • ENSG00000218336

Symbol
  • KIAA1455
  • ODZ3
  • TNM3
  • ODZ3
  • TNM3
  • ten-3
  • Ten-m3
  • MCOPCB9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
0.93
transcription factor perturbation
0.88
disease
0.71
interacting protein
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.86   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.86   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
DNAJC3
Tbio
Novelty:  0.02129782
p_int:  0.999993925
p_ni:  0.000006064
p_wrong:  1e-8
Data Source:  BioPlex
PLAC9
Tdark
Novelty:  0.23764669
p_int:  0.999983055
p_ni:  0.000016945
Data Source:  BioPlex
CST5
Tbio
Novelty:  0.04273227
p_int:  0.999893159
p_ni:  0.000106841
Data Source:  BioPlex
CLU
Tbio
Novelty:  0.00054776
p_int:  0.999738844
p_ni:  0.000261155
p_wrong:  1e-9
Score:  0.359
Data Source:  BioPlex,STRINGDB
HYOU1
Tbio
Novelty:  0.00833649
p_int:  0.996085969
p_ni:  0.003913998
p_wrong:  3.4e-8
Data Source:  BioPlex
LMAN2L
Tbio
Novelty:  0.04364985
p_int:  0.996004027
p_ni:  0.003995726
p_wrong:  2.46e-7
Score:  0.319
Data Source:  BioPlex,STRINGDB
PSG8
Tdark
Novelty:  0.1446257
p_int:  0.995291654
p_ni:  0.004413818
p_wrong:  0.000294528
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.991755164
p_ni:  0.008238793
p_wrong:  0.000006044
Data Source:  BioPlex
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.989472258
p_ni:  0.010076305
p_wrong:  0.000451437
Data Source:  BioPlex
SIAE
Tbio
Family:  Enzyme
Novelty:  0.01138067
p_int:  0.989441231
p_ni:  0.009188357
p_wrong:  0.001370412
Score:  0.286
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
65.9
neuroticism measurement
1
2
2
43.9
gut microbiome measurement
1
1
2
42.3
1
1
0
4
26.1
response to diisocyanate
1
1
0
4
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
65.9
neuroticism measurement
2
43.9
gut microbiome measurement
2
42.3
0
4
26.1
response to diisocyanate
0
4
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1345183
23965
Rat
RGD:1306641
306451
Dog
teneurin transmembrane protein 3
VGNC:47248
475637
Horse
teneurin transmembrane protein 3
VGNC:23999
100051352
Opossum
teneurin transmembrane protein 3
100012830
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
teneurin transmembrane protein 3
Horse
teneurin transmembrane protein 3
Opossum
teneurin transmembrane protein 3
Publication Statistics
PubMed Score 41.86
PubMed score by year
PubTator Score 45.14
PubTator score by year
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Related Publications
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PMID
Year
Title