Tbio TEKT2 Tektin-2

Protein Summary

Description

Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is expressed in the testis and its protein is localized to the flagella of the sperms, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UIF3
• A6NIS6
• O60638

Gene Name

• TEKT2

Ensembl ID

• ENST00000207457
• ENSP00000207457
• ENSG00000092850

Symbol

• TEKTB1
• TEKTIN-T
• h-tektin-t

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.72
cell type or tissue	0.7
gene perturbation	0.59
histone modification site profile	0.58
cell line	0.51

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Tektin-2

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Tektin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.42   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.42   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (57)

Explore Interacting Targets

1 – 10 of 57

• See Interactions on String-DB

CENPH

Tbio

Novelty:  0.02845079

p_int:  0.99996101

p_ni:  0.00003899

Score:  0.181

Data Source:  BioPlex,STRINGDB

PTER

Tbio

Family:  Enzyme

Novelty:  0.01347498

p_int:  0.999859451

p_ni:  0.000140541

p_wrong:  8e-9

Score:  0.189

Data Source:  BioPlex,STRINGDB

ACOT11

Tbio

Family:  Enzyme

Novelty:  0.0400726

p_int:  0.99885207

p_ni:  7.91e-7

p_wrong:  0.001147139

Score:  0.234

Data Source:  BioPlex,STRINGDB

GNB1L

Tbio

Novelty:  0.03388865

p_int:  0.984189987

p_ni:  0.015810013

Score:  0.157

Data Source:  BioPlex,STRINGDB

MMAB

Tbio

Family:  Enzyme

Novelty:  0.01681296

p_int:  0.940484829

p_ni:  0.059463833

p_wrong:  0.000051338

Score:  0.201

Data Source:  BioPlex,STRINGDB

KLHL42

Tdark

Novelty:  0.25822395

p_int:  0.939417058

p_ni:  0.060582939

p_wrong:  4e-9

Data Source:  BioPlex

GFAP

Tbio

Novelty:  0.00020932

p_int:  0.917475053

p_ni:  0.082524947

Data Source:  BioPlex

CCDC102A

Tdark

Novelty:  1.89784272

p_int:  0.90976404

p_ni:  0.089896285

p_wrong:  0.000339675

Score:  0.181

Data Source:  BioPlex,STRINGDB

CEP170

Tbio

Novelty:  0.05342931

p_int:  0.883924464

p_ni:  0.116075503

p_wrong:  3.3e-8

Score:  0.177

Data Source:  BioPlex,STRINGDB

PLCG1

Tchem

Family:  Enzyme

Novelty:  0.00110273

p_int:  0.881807532

p_ni:  0.117929489

p_wrong:  0.000262979

Score:  0.197

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Components (5)

Processes (4)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
nucleus	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
sperm flagellum	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
microtubule organizing center	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
cytoplasm	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
microtubule	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
intraocular pressure measurement	EFO_0004695	3	3	4		75.5
corneal topography	EFO_0004345	1	1	1		48.5
central corneal thickness	EFO_0005213	2	1	0	2.1	48.5
appendicular lean mass	EFO_0004980	1	1	1		21.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
intraocular pressure measurement	EFO_0004695	4		75.5
corneal topography	EFO_0004345	1		48.5
central corneal thickness	EFO_0005213	0	2.1	48.5
appendicular lean mass	EFO_0004980	1		21.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Cell projection
Cilium
Cilium biogenesis/degradation
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Flagellum
Microtubule

GWAS Trait Find Similar Targets

No Header	No Header
appendicular lean mass
central corneal thickness
corneal topography
intraocular pressure measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
reproductive system phenotype
respiratory system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tektin 2	VGNC:7005	456749
Macaque	tektin 2		712690
Mouse	tektin 2	MGI:1346335	24084
Rat	tektin 2	RGD:1311065	298532
Horse	tektin 2	VGNC:23994	100055105

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tektin 2
Macaque	tektin 2
Mouse	tektin 2
Rat	tektin 2
Horse	tektin 2

Publication Statistics

PubMed Score 22.42

PubMed score by year

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PubTator Score 9.12

PubTator score by year

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Related Publications

Text Mined References (12)

GeneRif Annotations (3)

Items per page:

10

0 of 0

PMID	Year	Title