Protein Summary
Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is expressed in the testis and its protein is localized to the flagella of the sperms, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
- ENST00000207457
- ENSP00000207457
- ENSG00000092850
- TEKTB1
- TEKTIN-T
- h-tektin-t
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cellular component | 0.72 | ||
cell type or tissue | 0.7 | ||
gene perturbation | 0.59 | ||
histone modification site profile | 0.58 | ||
cell line | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.42 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 128 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.42 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 128 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (57)
CENPH
Novelty: 0.02845079
p_int: 0.99996101
p_ni: 0.00003899
Score: 0.181
Data Source: BioPlex,STRINGDB
PTER
Family: Enzyme
Novelty: 0.01347498
p_int: 0.999859451
p_ni: 0.000140541
p_wrong: 8e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
ACOT11
Family: Enzyme
Novelty: 0.0400726
p_int: 0.99885207
p_ni: 7.91e-7
p_wrong: 0.001147139
Score: 0.234
Data Source: BioPlex,STRINGDB
GNB1L
Novelty: 0.03388865
p_int: 0.984189987
p_ni: 0.015810013
Score: 0.157
Data Source: BioPlex,STRINGDB
MMAB
Family: Enzyme
Novelty: 0.01681296
p_int: 0.940484829
p_ni: 0.059463833
p_wrong: 0.000051338
Score: 0.201
Data Source: BioPlex,STRINGDB
KLHL42
Novelty: 0.25822395
p_int: 0.939417058
p_ni: 0.060582939
p_wrong: 4e-9
Data Source: BioPlex
CCDC102A
Novelty: 1.89784272
p_int: 0.90976404
p_ni: 0.089896285
p_wrong: 0.000339675
Score: 0.181
Data Source: BioPlex,STRINGDB
CEP170
Novelty: 0.05342931
p_int: 0.883924464
p_ni: 0.116075503
p_wrong: 3.3e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
PLCG1
Family: Enzyme
Novelty: 0.00110273
p_int: 0.881807532
p_ni: 0.117929489
p_wrong: 0.000262979
Score: 0.197
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (9)
Components (5)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
intraocular pressure measurement | 3 | 3 | 4 | 75.5 | |||||
corneal topography | 1 | 1 | 1 | 48.5 | |||||
central corneal thickness | 2 | 1 | 0 | 2.1 | 48.5 | ||||
appendicular lean mass | 1 | 1 | 1 | 21.5 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
intraocular pressure measurement | 4 | 75.5 | |||||
corneal topography | 1 | 48.5 | |||||
central corneal thickness | 0 | 2.1 | 48.5 | ||||
appendicular lean mass | 1 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | tektin 2 | VGNC:7005 | 456749 | |||||
Macaque | tektin 2 | 712690 | ||||||
Mouse | MGI:1346335 | 24084 | ||||||
Rat | RGD:1311065 | 298532 | ||||||
Horse | tektin 2 | VGNC:23994 | 100055105 | |||||
Publication Statistics
PubMed Score 22.42
PubMed score by year
PubTator Score 9.12
PubTator score by year
Related Publications
Text Mined References (12)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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