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Tbio
TEKT2
Tektin-2

Protein Summary
Description
Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is expressed in the testis and its protein is localized to the flagella of the sperms, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000207457
  • ENSP00000207457
  • ENSG00000092850

Symbol
  • TEKTB1
  • TEKTIN-T
  • h-tektin-t
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.72
cell type or tissue
0.7
gene perturbation
0.59
histone modification site profile
0.58
cell line
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.42   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.42   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
CENPH
Tbio
Novelty:  0.02845079
p_int:  0.99996101
p_ni:  0.00003899
Score:  0.181
Data Source:  BioPlex,STRINGDB
PTER
Tbio
Family:  Enzyme
Novelty:  0.01347498
p_int:  0.999859451
p_ni:  0.000140541
p_wrong:  8e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
ACOT11
Tbio
Family:  Enzyme
Novelty:  0.0400726
p_int:  0.99885207
p_ni:  7.91e-7
p_wrong:  0.001147139
Score:  0.234
Data Source:  BioPlex,STRINGDB
GNB1L
Tbio
Novelty:  0.03388865
p_int:  0.984189987
p_ni:  0.015810013
Score:  0.157
Data Source:  BioPlex,STRINGDB
MMAB
Tbio
Family:  Enzyme
Novelty:  0.01681296
p_int:  0.940484829
p_ni:  0.059463833
p_wrong:  0.000051338
Score:  0.201
Data Source:  BioPlex,STRINGDB
KLHL42
Tdark
Novelty:  0.25822395
p_int:  0.939417058
p_ni:  0.060582939
p_wrong:  4e-9
Data Source:  BioPlex
GFAP
Tbio
Novelty:  0.00020932
p_int:  0.917475053
p_ni:  0.082524947
Data Source:  BioPlex
CCDC102A
Tdark
Novelty:  1.89784272
p_int:  0.90976404
p_ni:  0.089896285
p_wrong:  0.000339675
Score:  0.181
Data Source:  BioPlex,STRINGDB
CEP170
Tbio
Novelty:  0.05342931
p_int:  0.883924464
p_ni:  0.116075503
p_wrong:  3.3e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
PLCG1
Tchem
Family:  Enzyme
Novelty:  0.00110273
p_int:  0.881807532
p_ni:  0.117929489
p_wrong:  0.000262979
Score:  0.197
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
3
3
4
75.5
corneal topography
1
1
1
48.5
central corneal thickness
2
1
0
2.1
48.5
appendicular lean mass
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
75.5
corneal topography
1
48.5
central corneal thickness
0
2.1
48.5
appendicular lean mass
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tektin 2
VGNC:7005
456749
Macaque
tektin 2
712690
Mouse
MGI:1346335
24084
Rat
RGD:1311065
298532
Horse
tektin 2
VGNC:23994
100055105
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tektin 2
Macaque
tektin 2
Mouse
Rat
Horse
tektin 2
Publication Statistics
PubMed Score 22.42
PubMed score by year
PubTator Score 9.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title