Protein Summary
Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that ...more
- ENST00000380036
- ENSP00000369375
- ENSG00000120156
- ENST00000406359
- ENSP00000383977
- ENST00000519097
- ENSP00000430686
- TIE2
- VMCM
- VMCM1
- TIE2
- VMCM
- GLC3E
- TIE-2
- VMCM1
- CD202B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
protein domain | 1 | ||
molecular function | 0.98 | ||
transcription factor perturbation | 0.96 | ||
gene perturbation | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1199.03 (req: < 5)
Gene RIFs: 197 (req: <= 3)
Antibodies: 1276 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1199.03 (req: >= 5)
Gene RIFs: 197 (req: > 3)
Antibodies: 1276 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 50
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 248
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (248)
Protein-Protein Interactions (215)
Nearest Tclin Targets
Pathways (186)
Reactome (12)
KEGG (6)
PathwayCommons (3)
WikiPathways (165)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | FLT3 Signaling | ||||
Reactome | Hemostasis | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell surface interactions at the vascular wall | ||||
Cytokine Signaling in Immune system | ||||
FLT3 Signaling | ||||
Hemostasis | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (64)
Functions (8)
Components (14)
Processes (42)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
angiopoietin-1 receptor measurement | 1 | 2 | 2 | 96 | |||||
endothelial growth factor measurement | 1 | 1 | 1 | 85.7 | |||||
hepatocyte growth factor measurement | 1 | 1 | 1 | 85.7 | |||||
angiopoietin-2 receptor measurement | 1 | 1 | 1 | 85.7 | |||||
angiopoietin-2 measurement | 1 | 1 | 1 | 85.7 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
angiopoietin-1 receptor measurement | 2 | 96 | |||||
endothelial growth factor measurement | 1 | 85.7 | |||||
hepatocyte growth factor measurement | 1 | 85.7 | |||||
angiopoietin-2 receptor measurement | 1 | 85.7 | |||||
angiopoietin-2 measurement | 1 | 85.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | TEK receptor tyrosine kinase | VGNC:10114 | 465028 | |||||
Macaque | TEK receptor tyrosine kinase | 707455 | ||||||
Mouse | MGI:98664 | 21687 | ||||||
Rat | RGD:620980 | 89804 | ||||||
Dog | TEK receptor tyrosine kinase | VGNC:47241 | 403714 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | TEK receptor tyrosine kinase | |||||
Macaque | TEK receptor tyrosine kinase | |||||
Mouse | ||||||
Rat | ||||||
Dog | TEK receptor tyrosine kinase | |||||
Publication Statistics
PubMed Score 1199.03
PubMed score by year
PubTator Score 706.74
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (237)
GeneRif Annotations (197)
Items per page:
0 of 0
PMID | Year | Title |
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