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Tclin
TEK
Angiopoietin-1 receptor

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380036
  • ENSP00000369375
  • ENSG00000120156
  • ENST00000406359
  • ENSP00000383977
  • ENST00000519097
  • ENSP00000430686

Symbol
  • TIE2
  • VMCM
  • VMCM1
  • TIE2
  • VMCM
  • GLC3E
  • TIE-2
  • VMCM1
  • CD202B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
1
molecular function
0.98
transcription factor perturbation
0.96
gene perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1302.94   (req: < 5)
Gene RIFs: 197   (req: <= 3)
Antibodies: 1276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1302.94   (req: >= 5)
Gene RIFs: 197   (req: > 3)
Antibodies: 1276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 250
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4