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Tbio
TEFM
Transcription elongation factor, mitochondrial

Protein Summary
Description
Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306049
  • ENSP00000306574
  • ENSG00000172171
  • ENST00000581216
  • ENSP00000462963

Symbol
  • C17orf42
  • C17orf42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor binding site profile
0.86
interacting protein
0.81
molecular function
0.73
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.18   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.18   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
A2ML1
Tbio
Novelty:  0.05923067
p_int:  0.999996546
p_ni:  0.000003454
Data Source:  BioPlex
SERPINA3
Tbio
Novelty:  0.00134253
p_int:  0.999977405
p_ni:  0.000022595
Data Source:  BioPlex
LCN2
Tbio
Family:  Enzyme
Novelty:  0.00034678
p_int:  0.999919543
p_ni:  0.000080457
Data Source:  BioPlex
IVL
Tbio
Novelty:  0.00147892
p_int:  0.999898573
p_ni:  0.000101427
Data Source:  BioPlex
TYMP
Tclin
Family:  Enzyme
Novelty:  0.0015906
p_int:  0.999870408
p_ni:  0.000129592
Data Source:  BioPlex
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.999863241
p_ni:  0.00012772
p_wrong:  0.000009039
Data Source:  BioPlex
KLK10
Tbio
Family:  Enzyme
Novelty:  0.00899521
p_int:  0.999832682
p_ni:  0.00016292
p_wrong:  0.000004397
Data Source:  BioPlex
ACPP
Tchem
Family:  Enzyme
Novelty:  0.00364265
p_int:  0.999767832
p_ni:  0.000232162
p_wrong:  6e-9
Data Source:  BioPlex
CAPNS2
Tbio
Novelty:  0.45658116
p_int:  0.999662259
p_ni:  0.000085769
p_wrong:  0.000251973
Data Source:  BioPlex
CTSH
Tchem
Family:  Enzyme
Novelty:  0.00336694
p_int:  0.999107668
p_ni:  0.000892202
p_wrong:  1.29e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
8
10
94.1
BMI-adjusted waist circumference
4
5
8
92.2
body height
3
2
2
6
92
mean corpuscular volume
2
2
2
89.9
body weights and measures
1
1
1
86.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
10
94.1
BMI-adjusted waist circumference
8
92.2
body height
2
6
92
mean corpuscular volume
2
89.9
body weights and measures
1
86.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription elongation factor, mitochondrial
VGNC:9684
454560
Mouse
MGI:1915800
68550
Rat
RGD:1306595
287554
Dog
transcription elongation factor, mitochondrial
VGNC:47240
480615
Horse
transcription elongation factor, mitochondrial
VGNC:23991
100071813
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription elongation factor, mitochondrial
Mouse
Rat
Dog
transcription elongation factor, mitochondrial
Horse
transcription elongation factor, mitochondrial
Publication Statistics
PubMed Score 11.18
PubMed score by year
PubTator Score 3.92
PubTator score by year
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Related Publications
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PMID
Year
Title