Protein Summary
One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. This gene encodes a non-collagenous glycoprotein component of the tectorial membrane, which covers the auditory hair cells in the cochlea of the inner ear. A similar protein in mouse functions in low-frequency hearing. [provided by RefSeq, Jul 2013]
- ENST00000369422
- ENSP00000358430
- ENSG00000119913
- ENST00000646139
- ENSP00000494896
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.59 | ||
gene perturbation | 0.47 | ||
cell line | 0.45 | ||
cell type or tissue | 0.35 | ||
biological term | 0.34 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.32 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 89 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.32 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 89 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (106)
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational modification: synthesis of GPI-anchored proteins | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational modification: synthesis of GPI-anchored proteins | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (1)
Components (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 3 | 6 | 97.1 | |||||
high density lipoprotein cholesterol measurement | 6 | 5 | 10 | 93.5 | |||||
total cholesterol measurement | 4 | 4 | 7 | 87.6 | |||||
alkaline phosphatase measurement | 3 | 2 | 2 | 12.3 | 87.4 | ||||
low density lipoprotein cholesterol measurement | 2 | 2 | 5 | 83.4 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 6 | 97.1 | |||||
high density lipoprotein cholesterol measurement | 10 | 93.5 | |||||
total cholesterol measurement | 7 | 87.6 | |||||
alkaline phosphatase measurement | 2 | 12.3 | 87.4 | ||||
low density lipoprotein cholesterol measurement | 5 | 83.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tectorin beta | VGNC:12508 | 466202 | |||||
Macaque | tectorin beta | 696153 | ||||||
Mouse | MGI:109574 | 21684 | ||||||
Rat | RGD:1305835 | 292124 | ||||||
Dog | tectorin beta | VGNC:47237 | 486891 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tectorin beta | |||||
Macaque | tectorin beta | |||||
Mouse | ||||||
Rat | ||||||
Dog | tectorin beta | |||||
Publication Statistics
PubMed Score 23.32
PubMed score by year
PubTator Score 3.23
PubTator score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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