Protein Summary
One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant ...more
- ENST00000264037
- ENSP00000264037
- ENSG00000109927
- ENST00000392793
- ENSP00000376543
- DFNA8
- DFNA12
- DFNB21
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
tissue sample | 0.61 | ||
gene perturbation | 0.58 | ||
cell type or tissue | 0.54 | ||
cell line | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.02 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 27 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.02 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 27 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (83)
Nearest Tclin Targets
Pathways (3)
Reactome (3)
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Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational modification: synthesis of GPI-anchored proteins | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational modification: synthesis of GPI-anchored proteins | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (1)
Components (5)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:109575 | 21683 | ||||||
Rat | RGD:1309824 | 300653 | ||||||
Dog | tectorin alpha | VGNC:47236 | 489357 | |||||
Horse | tectorin alpha | VGNC:23987 | 100063512 | |||||
Cow | tectorin alpha | VGNC:35732 | 533133 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | tectorin alpha | |||||
Horse | tectorin alpha | |||||
Cow | tectorin alpha | |||||
Publication Statistics
PubMed Score 39.02
PubMed score by year
PubTator Score 79.84
PubTator score by year
Related Publications
Text Mined References (40)
GeneRif Annotations (31)
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