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Tbio
TECTA
Alpha-tectorin

Protein Summary
Description
One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264037
  • ENSP00000264037
  • ENSG00000109927
  • ENST00000392793
  • ENSP00000376543

Symbol
  • DFNA8
  • DFNA12
  • DFNB21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
tissue sample
0.61
gene perturbation
0.58
cell type or tissue
0.54
cell line
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.02   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.02   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
OTOA
Tbio
Novelty:  0.04940755
Score:  0.979
Data Source:  STRINGDB
TECTB
Tbio
Novelty:  0.04489491
Score:  0.935
Data Source:  STRINGDB
MDGA2
Tbio
Novelty:  0.07784646
Score:  0.926
Data Source:  STRINGDB
NTNG1
Tbio
Novelty:  0.04742965
Score:  0.907
Data Source:  STRINGDB
ALPL
Tchem
Family:  Enzyme
Novelty:  0.00152281
Score:  0.906
Data Source:  STRINGDB
ALPI
Tchem
Family:  Enzyme
Novelty:  0.00559196
Score:  0.906
Data Source:  STRINGDB
ALPG
Tchem
Family:  Enzyme
Novelty:  0.00577814
Score:  0.906
Data Source:  STRINGDB
NTNG2
Tbio
Novelty:  0.02827688
Score:  0.905
Data Source:  STRINGDB
GP2
Tbio
Novelty:  0.00126542
Score:  0.905
Data Source:  STRINGDB
CNTN5
Tbio
Novelty:  0.00601105
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:109575
21683
Rat
RGD:1309824
300653
Dog
tectorin alpha
VGNC:47236
489357
Horse
tectorin alpha
VGNC:23987
100063512
Cow
tectorin alpha
VGNC:35732
533133
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
tectorin alpha
Horse
tectorin alpha
Cow
tectorin alpha
Publication Statistics
PubMed Score 39.02
PubMed score by year
PubTator Score 79.84
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title