Tbio TECRL Trans-2,3-enoyl-CoA reductase-like

Protein Summary

Description

The protein encoded by this gene contains a ubiquitin-like domain in the N-terminal region, three transmembrane segments and a C-terminal 3-oxo-5-alpha steroid 4-dehydrogenase domain. The protein belongs to the steroid 5-alpha reductase family. Mutations in this gene result in ventricular tachycardia, catecholaminergic polymorphic, 3. [provided by RefSeq, Apr 2017]

Uniprot Accession IDs

• Q5HYJ1

Gene Name

• TECRL

Ensembl ID

• ENST00000381210
• ENSP00000370607
• ENSG00000205678

Symbol

• SRD5A2L2
• TERL
• CPVT3
• GPSN2L
• SRD5A2L2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.9
gene perturbation	0.88
cell type or tissue	0.7
disease	0.55
phenotype	0.5

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Trans-2,3-enoyl-coa Reductase-like

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Trans-2,3-enoyl-coa Reductase-like

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162.67   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 79   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162.67   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0