Tbio TECR Very-long-chain enoyl-CoA reductase

Protein Summary

Description

Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]

Uniprot Accession IDs

• Q9NZ01
• B2RD55
• O75350
• Q6IBB2
• Q9BWK3
• Q9Y6P0

Gene Name

• TECR

Ensembl ID

• ENST00000215567
• ENSP00000215567
• ENSG00000099797

Symbol

• GPSN2
• SC2
• SC2
• TER
• GPSN2
• MRT14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
transcription factor perturbation	0.97
tissue	0.71
cellular component	0.68
transcription factor binding site profile	0.67

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Very-long-chain Enoyl-coa Reductase

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Very-long-chain Enoyl-coa Reductase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1288.05   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1288.05   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0