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Tbio
TECPR2
Tectonin beta-propeller repeat-containing protein 2

Protein Summary
Description
Probably plays a role as positive regulator of autophagy. The protein encoded by this gene is a member of the tectonin beta-propeller repeat-containing (TECPR) family, and contains both TECPR and tryptophan-aspartic acid repeat (WD repeat) domains. This gene has been implicated in autophagy, as reduced expression levels of this gene have been associated with impaired autophagy. Recessive mutations in this gene have been associated with a hereditary form of spastic paraparesis (HSP). HSP is characterized by progressive spasticity and paralysis of the legs. There is also some evidence linking mutations in this gene with birdshot chorioretinopathy (BSCR), which results in inflammation of the choroid and retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359520
  • ENSP00000352510
  • ENSG00000196663
  • ENST00000558678
  • ENSP00000453671

Symbol
  • KIAA0297
  • KIAA0329
  • SPG49
  • KIAA0329
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
protein domain
0.85
virus perturbation
0.68
cell type or tissue
0.66
cell line
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.33   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.33   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
VPS41
Tbio
Novelty:  0.08480171
p_int:  0.999999934
p_ni:  5.5e-8
p_wrong:  1.1e-8
Score:  0.86
Data Source:  BioPlex,STRINGDB
VPS18
Tbio
Novelty:  0.00726539
p_int:  0.999696329
p_ni:  0.000303671
Score:  0.816
Data Source:  BioPlex,STRINGDB
VPS16
Tbio
Novelty:  0.03575558
p_int:  0.996990802
p_ni:  0.003009198
Score:  0.819
Data Source:  BioPlex,STRINGDB
PPM1A
Tchem
Family:  Enzyme
Novelty:  0.01464968
p_int:  0.996212983
p_ni:  0.003787016
Score:  0.187
Data Source:  BioPlex,STRINGDB
NUDCD3
Tbio
Novelty:  0.32026811
p_int:  0.993916869
p_ni:  0.006083131
Score:  0.189
Data Source:  BioPlex,STRINGDB
DNAJB5
Tbio
Novelty:  0.20703358
p_int:  0.861178796
p_ni:  0.137017579
p_wrong:  0.001803625
Score:  0.169
Data Source:  BioPlex,STRINGDB
TRAPPC12
Tbio
Novelty:  0.09847363
Score:  0.654
Data Source:  STRINGDB
MFN2
Tbio
Novelty:  0.00137876
Score:  0.652
Data Source:  STRINGDB
EPG5
Tbio
Novelty:  0.02959841
Score:  0.641
Data Source:  STRINGDB
TRAPPC5
Tdark
Novelty:  0.22558077
Score:  0.625
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
6
5
2.6
89.4
mean corpuscular volume
2
2
2
77.6
platelet crit
2
2
2
68.8
eosinophil count
2
1
2
66.3
eosinophil percentage of leukocytes
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
2.6
89.4
mean corpuscular volume
2
77.6
platelet crit
2
68.8
eosinophil count
2
66.3
eosinophil percentage of leukocytes
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tectonin beta-propeller repeat containing 2
VGNC:10316
453177
Mouse
MGI:2144865
104859
Rat
RGD:1307503
314456
Dog
tectonin beta-propeller repeat containing 2
VGNC:47233
490864
Horse
tectonin beta-propeller repeat containing 2
VGNC:23984
100058537
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tectonin beta-propeller repeat containing 2
Mouse
Rat
Dog
tectonin beta-propeller repeat containing 2
Horse
tectonin beta-propeller repeat containing 2
Publication Statistics
PubMed Score 10.33
PubMed score by year
PubTator Score 5.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title