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Tbio
TDRKH
Tudor and KH domain-containing protein

Protein Summary
Description
Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368822
  • ENSP00000357812
  • ENSG00000182134
  • ENST00000368824
  • ENSP00000357815
  • ENST00000368825
  • ENSP00000357817
  • ENST00000368827
  • ENSP00000357819
  • ENST00000458431
  • ENSP00000395718

Symbol
  • TDRD2
  • TDRD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
tissue sample
0.62
trait
0.61
microRNA
0.6
transcription factor binding site profile
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.47   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.47   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
ARHGAP19
Tbio
Family:  Enzyme
Novelty:  0.19587262
p_int:  0.956646497
p_ni:  0.043353503
Score:  0.54
Data Source:  BioPlex,STRINGDB
PIWIL1
Tbio
Novelty:  0.00095911
Score:  0.984
Data Source:  Reactome,STRINGDB
PIWIL4
Tbio
Novelty:  0.00105088
Score:  0.983
Data Source:  Reactome,STRINGDB
TDRD12
Tdark
Family:  Epigenetic
Novelty:  0.2276017
Score:  0.978
Data Source:  STRINGDB
PIWIL2
Tbio
Novelty:  0.00907402
Score:  0.969
Data Source:  STRINGDB
HENMT1
Tdark
Family:  Enzyme
Novelty:  0.17427834
Score:  0.967
Data Source:  Reactome,STRINGDB
MAEL
Tbio
Novelty:  0.01925239
Score:  0.965
Data Source:  Reactome,STRINGDB
ASZ1
Tbio
Novelty:  0.0011137
Score:  0.959
Data Source:  STRINGDB
TDRD1
Tbio
Family:  Epigenetic
Novelty:  0.04645566
Score:  0.959
Data Source:  STRINGDB
MOV10L1
Tbio
Family:  Enzyme
Novelty:  0.09735465
Score:  0.956
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene Silencing by RNA (R-HSA-211000)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
PIWI-interacting RNA (piRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
PIWI-interacting RNA (piRNA) biogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
1
2
81.7
blood metabolite measurement
1
2
2
81.1
2
3
0
1.1
77.1
vitamin D measurement
1
2
2
73.6
1
1
0
1.1
73.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
81.7
blood metabolite measurement
2
81.1
0
1.1
77.1
vitamin D measurement
2
73.6
0
1.1
73.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tudor and KH domain containing
VGNC:1669
469487
Macaque
tudor and KH domain containing
716968
Mouse
MGI:1919884
72634
Rat
RGD:1311196
310652
Dog
tudor and KH domain containing
VGNC:47227
609125
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tudor and KH domain containing
Macaque
tudor and KH domain containing
Mouse
Rat
Dog
tudor and KH domain containing
Publication Statistics
PubMed Score 8.47
PubMed score by year
PubTator Score 2.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title