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Tdark
TDRD5
Tudor domain-containing protein 5

Protein Summary
Description
Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294848
  • ENSP00000294848
  • ENSG00000162782
  • ENST00000367614
  • ENSP00000356586
  • ENST00000444136
  • ENSP00000406052

Symbol
  • TUDOR3
  • TUDOR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.67
gene perturbation
0.65
cell line
0.61
cell type or tissue
0.56
interacting protein
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.74   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 17   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.74   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
TDRD9
Tbio
Family:  Epigenetic
Novelty:  0.10913126
Score:  0.98
Data Source:  STRINGDB
PIWIL4
Tbio
Novelty:  0.00105088
Score:  0.962
Data Source:  STRINGDB
MAEL
Tbio
Novelty:  0.01925239
Score:  0.946
Data Source:  STRINGDB
MOV10L1
Tbio
Family:  Enzyme
Novelty:  0.09735465
Score:  0.942
Data Source:  STRINGDB
PIWIL1
Tbio
Novelty:  0.00095911
Score:  0.941
Data Source:  STRINGDB
PIWIL2
Tbio
Novelty:  0.00907402
Score:  0.933
Data Source:  STRINGDB
HENMT1
Tdark
Family:  Enzyme
Novelty:  0.17427834
Score:  0.9
Data Source:  STRINGDB
TDRD1
Tbio
Family:  Epigenetic
Novelty:  0.04645566
Score:  0.893
Data Source:  STRINGDB
TDRD12
Tdark
Family:  Epigenetic
Novelty:  0.2276017
Score:  0.891
Data Source:  STRINGDB
DDX4
Tbio
Family:  Enzyme
Novelty:  0.00692586
Score:  0.878
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
2
2
75.4
thrombomodulin measurement
1
1
1
71.9
smoking status measurement
2
1
2
61
tumor necrosis factor receptor II measurement
1
1
1
54.5
vitamin D measurement
1
1
1
17.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
75.4
thrombomodulin measurement
1
71.9
smoking status measurement
2
61
tumor necrosis factor receptor II measurement
1
54.5
vitamin D measurement
1
17.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tudor domain containing 5
VGNC:1670
457554
Macaque
tudor domain containing 5
716831
Mouse
MGI:2684949
214575
Rat
RGD:1307078
289129
Dog
tudor domain containing 5
VGNC:47223
480050
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tudor domain containing 5
Macaque
tudor domain containing 5
Mouse
Rat
Dog
tudor domain containing 5
Publication Statistics
PubMed Score 10.74
PubMed score by year
PubTator Score 3.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title