You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TDRD3
Tudor domain-containing protein 3

Protein Summary
Description
Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000196169
  • ENSP00000196169
  • ENSG00000083544
  • ENST00000377881
  • ENSP00000367113
  • ENST00000377894
  • ENSP00000367126
  • ENST00000535286
  • ENSP00000440190
  • ENST00000621840
  • ENSP00000477993
  • ENST00000648252
  • ENSP00000498191
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
transcription factor perturbation
0.84
virus perturbation
0.76
transcription factor
0.67
cell line
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.21   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.21   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0