TDP1
Tyrosyl-DNA phosphodiesterase 1
Protein Summary
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime ph ...more
- ENST00000335725
- ENSP00000337353
- ENSG00000042088
- ENST00000393454
- ENSP00000377099
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.86 | ||
kinase perturbation | 0.81 | ||
transcription factor binding site profile | 0.69 | ||
molecular function | 0.67 | ||
tissue | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 218.78 (req: < 5)
Gene RIFs: 54 (req: <= 3)
Antibodies: 309 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 218.78 (req: >= 5)
Gene RIFs: 54 (req: > 3)
Antibodies: 309 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 79
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (79)
Protein-Protein Interactions (90)
POLB
Family: Enzyme
Novelty: 0.00145102
p_int: 0.999999978
p_ni: 2e-8
p_wrong: 2e-9
Score: 0.831
Data Source: BioPlex,STRINGDB
CETN1
Novelty: 0.01208917
p_int: 0.999999547
p_ni: 3.57e-7
p_wrong: 9.6e-8
Score: 0.194
Data Source: BioPlex,STRINGDB
CSNK1D
Family: Kinase
Novelty: 0.00896935
p_int: 0.99975629
p_ni: 0.000242081
p_wrong: 0.000001628
Score: 0.186
Data Source: BioPlex,STRINGDB
APLF
Novelty: 0.01347476
p_int: 0.99969278
p_ni: 0.000304918
p_wrong: 0.000002303
Score: 0.776
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (3)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | DNA Double-Strand Break Repair | ||||
Reactome | DNA Repair | ||||
Reactome | Nonhomologous End-Joining (NHEJ) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
DNA Double-Strand Break Repair | ||||
DNA Repair | ||||
Nonhomologous End-Joining (NHEJ) | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (4)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 2.2 | 46.1 | |||||
1 | 1 | 0 | 2.3 | 36.5 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 2.2 | 46.1 | |||||
0 | 2.3 | 36.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tyrosyl-DNA phosphodiesterase 1 | VGNC:6768 | 453096 | |||||
Macaque | tyrosyl-DNA phosphodiesterase 1 | 695338 | ||||||
Mouse | MGI:1920036 | 104884 | ||||||
Rat | RGD:1309618 | 314380 | ||||||
Dog | tyrosyl-DNA phosphodiesterase 1 | VGNC:47218 | 490828 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tyrosyl-DNA phosphodiesterase 1 | |||||
Macaque | tyrosyl-DNA phosphodiesterase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tyrosyl-DNA phosphodiesterase 1 | |||||
Publication Statistics
PubMed Score 218.78
PubMed score by year
PubTator Score 112.12
PubTator score by year
Related Publications
Text Mined References (67)
GeneRif Annotations (54)
Items per page:
0 of 0
PMID | Year | Title |
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