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Tbio
TDGF1
Teratocarcinoma-derived growth factor 1

Protein Summary
Description
GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953). This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296145
  • ENSP00000296145
  • ENSG00000241186

Symbol
  • CRIPTO
  • CR
  • CR-1
  • CRGF
  • CRIPTO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
cellular component
0.69
PubMedID
0.61
microRNA
0.6
biological term
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.34   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 602   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.34   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 602   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
RMND5B
Tbio
Novelty:  0.08447048
p_int:  0.999755921
p_ni:  0.00010337
p_wrong:  0.000140709
Score:  0.2
Data Source:  BioPlex,STRINGDB
IL18
Tbio
Novelty:  0.00022844
p_int:  0.999090533
p_ni:  0.00089975
p_wrong:  0.000009716
Score:  0.189
Data Source:  BioPlex,STRINGDB
GID4
Tbio
Novelty:  0.05252674
p_int:  0.99888559
p_ni:  0.00111441
Score:  0.232
Data Source:  BioPlex,STRINGDB
ZMYND19
Tdark
Novelty:  0.3590069
p_int:  0.998879813
p_ni:  0.001120187
Score:  0.666
Data Source:  BioPlex,STRINGDB
ARMC8
Tbio
Novelty:  0.06820746
p_int:  0.994210067
p_ni:  0.005789933
Score:  0.303
Data Source:  BioPlex,STRINGDB
GID8
Tbio
Novelty:  0.21243963
p_int:  0.987881985
p_ni:  0.012118015
Score:  0.547
Data Source:  BioPlex,STRINGDB
RMND5A
Tbio
Novelty:  0.01820349
p_int:  0.981919523
p_ni:  0.018080477
Score:  0.813
Data Source:  BioPlex,STRINGDB
MKLN1
Tbio
Novelty:  0.05014385
p_int:  0.969673768
p_ni:  0.030326232
Score:  0.303
Data Source:  BioPlex,STRINGDB
AIP
Tbio
Novelty:  0.00869592
p_int:  0.966939174
p_ni:  0.033060826
Score:  0.198
Data Source:  BioPlex,STRINGDB
WDR26
Tbio
Novelty:  0.04140166
p_int:  0.945804094
p_ni:  0.054195906
Score:  0.562
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Reactome
Regulation of signaling by NODAL
Reactome
Signaling by NODAL
Reactome
Transcriptional regulation of pluripotent stem cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Regulation of signaling by NODAL
Signaling by NODAL
Transcriptional regulation of pluripotent stem cells
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
1
1
87
CCL2 measurement
1
1
1
49.5
1
1
1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
87
CCL2 measurement
1
49.5
1
1.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
teratocarcinoma-derived growth factor 1
740372
Mouse
MGI:98658
21667
Rat
RGD:1594185
680246
Horse
teratocarcinoma-derived growth factor 1
100065218
Pig
teratocarcinoma-derived growth factor 1 [Source:HGNC Symbol;Acc:HGNC:11701]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
teratocarcinoma-derived growth factor 1
Mouse
Rat
Horse
teratocarcinoma-derived growth factor 1
Pig
teratocarcinoma-derived growth factor 1 [Source:HGNC Symbol;Acc:HGNC:11701]
Publication Statistics
PubMed Score 232.34
PubMed score by year
PubTator Score 45.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title