Tdark TCTN3 Tectonic-3

Protein Summary

Description

Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway. This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]

Uniprot Accession IDs

• Q6NUS6
• A6NIC8
• B0QZ90
• B4DR81
• Q6P7P3
• Q6UW27
• Q6ZQQ0
• Q8N7K1
• Q8NBQ0
• Q96GF7
• Q9Y3U1

Gene Name

• TCTN3

Ensembl ID

• ENST00000371209
• ENSP00000360253
• ENSG00000119977
• ENST00000371217
• ENSP00000360261
• ENST00000430368
• ENSP00000387567
• ENST00000614499
• ENSP00000483364

Symbol

• C10orf61
• TECT3
• OFD4
• TECT3
• JBTS18
• C10orf61

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.9
kinase perturbation	0.88
tissue sample	0.71
disease perturbation	0.62
cellular component	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.88   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 181   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.88   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (129)

Explore Interacting Targets

1 – 10 of 129

• See Interactions on String-DB

TRIM68

Tbio

Family:  Enzyme

Novelty:  0.11729189

p_int:  0.998135099

p_ni:  0.001864885

p_wrong:  1.6e-8

Data Source:  BioPlex

CTSH

Tchem

Family:  Enzyme

Novelty:  0.00336694

p_int:  0.986201301

p_ni:  0.011823769

p_wrong:  0.00197493

Score:  0.219

Data Source:  BioPlex,STRINGDB

ADAMTS2

Tbio

Family:  Enzyme

Novelty:  0.00852208

p_int:  0.967148329

p_ni:  0.032851432

p_wrong:  2.39e-7

Data Source:  BioPlex

TUBB8

Tclin

Novelty:  0.06403117

p_int:  0.942328652

p_ni:  0.057671348

Data Source:  BioPlex

GPAA1

Tbio

Novelty:  0.01874575

p_int:  0.92718172

p_ni:  0.07281828

Data Source:  BioPlex

KCNJ8

Tbio

Family:  IC

Novelty:  0.00369886

p_int:  0.927078779

p_ni:  0.072920975

p_wrong:  2.46e-7

Data Source:  BioPlex

SERPINA12

Tbio

Novelty:  0.00549132

p_int:  0.865998424

p_ni:  0.134001576

Score:  0.187

Data Source:  BioPlex,STRINGDB

CPA4

Tchem

Family:  Enzyme

Novelty:  0.01439845

p_int:  0.841959246

p_ni:  0.158040442

p_wrong:  3.12e-7

Score:  0.19

Data Source:  BioPlex,STRINGDB

KPRP

Tdark

Novelty:  0.11744927

p_int:  0.820199958

p_ni:  0.171716711

p_wrong:  0.008083332

Score:  0.198

Data Source:  BioPlex,STRINGDB

TGM1

Tchem

Family:  Enzyme

Novelty:  0.00103799

p_int:  0.789064544

p_ni:  0.210935456

Score:  0.177

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (3)

WikiPathways (2)

Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Reactome	Cilium Assembly	187 targets	R-HSA-5617833
Reactome	Organelle biogenesis and maintenance	276 targets	R-HSA-1852241

Name	Explore in Pharos	Explore in Source
Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Cilium Assembly	187 targets	R-HSA-5617833
Organelle biogenesis and maintenance	276 targets	R-HSA-1852241

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Components (3)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
nucleus	Inferred from Direct Assay (IDA)	UniProtKB
ciliary membrane	Traceable Author Statement (TAS)	Reactome
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
electrocardiography	EFO_0004327	1	1	9		64
blood metabolite measurement	EFO_0005664	1	1	1		45.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
electrocardiography	EFO_0004327	9		64
blood metabolite measurement	EFO_0005664	1		45.7

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Apoptosis
Ciliopathy
Cilium biogenesis/degradation
Complete proteome
Disease mutation
Glycoprotein
Joubert syndrome
Membrane
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
blood metabolite measurement
electrocardiography

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tectonic family member 3	VGNC:5814	450631
Macaque	tectonic family member 3		703844
Mouse	tectonic family member 3	MGI:1914840	67590
Dog	tectonic family member 3	VGNC:47215	608523
Horse	tectonic family member 3	VGNC:23969	100070964

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tectonic family member 3
Macaque	tectonic family member 3
Mouse	tectonic family member 3
Dog	tectonic family member 3
Horse	tectonic family member 3

Publication Statistics

PubMed Score 4.88

PubMed score by year

Reset Zoom

PubTator Score 2.07

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (12)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title