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Tdark
TCTN3
Tectonic-3

Protein Summary
Description
Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway. This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371209
  • ENSP00000360253
  • ENSG00000119977
  • ENST00000371217
  • ENSP00000360261
  • ENST00000430368
  • ENSP00000387567
  • ENST00000614499
  • ENSP00000483364

Symbol
  • C10orf61
  • TECT3
  • OFD4
  • TECT3
  • JBTS18
  • C10orf61
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
kinase perturbation
0.88
tissue sample
0.71
disease perturbation
0.62
cellular component
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.88   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.88   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (129)
TRIM68
Tbio
Family:  Enzyme
Novelty:  0.11729189
p_int:  0.998135099
p_ni:  0.001864885
p_wrong:  1.6e-8
Data Source:  BioPlex
CTSH
Tchem
Family:  Enzyme
Novelty:  0.00336694
p_int:  0.986201301
p_ni:  0.011823769
p_wrong:  0.00197493
Score:  0.219
Data Source:  BioPlex,STRINGDB
ADAMTS2
Tbio
Family:  Enzyme
Novelty:  0.00852208
p_int:  0.967148329
p_ni:  0.032851432
p_wrong:  2.39e-7
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.942328652
p_ni:  0.057671348
Data Source:  BioPlex
GPAA1
Tbio
Novelty:  0.01874575
p_int:  0.92718172
p_ni:  0.07281828
Data Source:  BioPlex
KCNJ8
Tbio
Family:  IC
Novelty:  0.00369886
p_int:  0.927078779
p_ni:  0.072920975
p_wrong:  2.46e-7
Data Source:  BioPlex
SERPINA12
Tbio
Novelty:  0.00549132
p_int:  0.865998424
p_ni:  0.134001576
Score:  0.187
Data Source:  BioPlex,STRINGDB
CPA4
Tchem
Family:  Enzyme
Novelty:  0.01439845
p_int:  0.841959246
p_ni:  0.158040442
p_wrong:  3.12e-7
Score:  0.19
Data Source:  BioPlex,STRINGDB
KPRP
Tdark
Novelty:  0.11744927
p_int:  0.820199958
p_ni:  0.171716711
p_wrong:  0.008083332
Score:  0.198
Data Source:  BioPlex,STRINGDB
TGM1
Tchem
Family:  Enzyme
Novelty:  0.00103799
p_int:  0.789064544
p_ni:  0.210935456
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
9
64
blood metabolite measurement
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
9
64
blood metabolite measurement
1
45.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tectonic family member 3
VGNC:5814
450631
Macaque
tectonic family member 3
703844
Mouse
MGI:1914840
67590
Dog
tectonic family member 3
VGNC:47215
608523
Horse
tectonic family member 3
VGNC:23969
100070964
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tectonic family member 3
Macaque
tectonic family member 3
Mouse
Dog
tectonic family member 3
Horse
tectonic family member 3
Publication Statistics
PubMed Score 4.88
PubMed score by year
PubTator Score 2.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title