Tbio TCTN2 Tectonic-2

Protein Summary

Description

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity). This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q96GX1
• A8K7Y8
• B3KPW5
• Q9H966

Gene Name

• TCTN2

Ensembl ID

• ENST00000303372
• ENSP00000304941
• ENSG00000168778
• ENST00000426174
• ENSP00000395171

Symbol

• C12orf38
• TECT2
• MKS8
• TECT2
• JBTS24
• C12orf38

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.76
histone modification site profile	0.75
cell line	0.61
cell type or tissue	0.6
small molecule perturbation	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.46   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.46   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (221)

Explore Interacting Targets

1 – 10 of 221

• See Interactions on String-DB

TMEM231

Tbio

Novelty:  0.17100188

p_int:  0.99999996

p_ni:  4e-8

Score:  0.943

Data Source:  BioPlex,STRINGDB

PIGB

Tbio

Family:  Enzyme

Novelty:  0.05237713

p_int:  0.999977147

p_ni:  0.000022846

p_wrong:  7e-9

Data Source:  BioPlex

ALG12

Tbio

Family:  Enzyme

Novelty:  0.03785588

p_int:  0.999831275

p_ni:  0.000168725

Data Source:  BioPlex

GLRB

Tclin

Family:  IC

Novelty:  0.01721113

p_int:  0.999803439

p_ni:  0.000196561

p_wrong:  1e-9

Data Source:  BioPlex

JMJD8

Tbio

Novelty:  0.31175159

p_int:  0.999483461

p_ni:  0.000514451

p_wrong:  0.000002088

Data Source:  BioPlex

NXPE3

Tdark

Novelty:  1.5063521

p_int:  0.999427312

p_ni:  0.000568913

p_wrong:  0.000003775

Data Source:  BioPlex

TMEM8A

Tdark

Novelty:  0.15724279

p_int:  0.999413191

p_ni:  0.000113393

p_wrong:  0.000473416

Data Source:  BioPlex

HLA-DMB

Tbio

Novelty:  0.02289537

p_int:  0.998623601

p_ni:  0.000133386

p_wrong:  0.001243013

Score:  0.307

Data Source:  BioPlex,STRINGDB

GRID1

Tbio

Family:  IC

Novelty:  0.05041468

p_int:  0.997981417

p_ni:  0.001969736

p_wrong:  0.000048847

Data Source:  BioPlex

JAG2

Tbio

Novelty:  0.00176158

p_int:  0.997757763

p_ni:  0.002242216

p_wrong:  2.1e-8

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (18)

Reactome (3)

WikiPathways (15)

Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

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Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Reactome	Cilium Assembly	187 targets	R-HSA-5617833
Reactome	Organelle biogenesis and maintenance	276 targets	R-HSA-1852241

Name	Explore in Pharos	Explore in Source
Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Cilium Assembly	187 targets	R-HSA-5617833
Organelle biogenesis and maintenance	276 targets	R-HSA-1852241

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Components (5)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
MKS complex	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
ciliary membrane	Traceable Author Statement (TAS)	Reactome
cytoplasm	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
cytoskeleton	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (13)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	1	11	11		97
BMI-adjusted waist-hip ratio	EFO_0007788	6	12	16		96.9
waist circumference	EFO_0004342	1	7	7		93.9
BMI-adjusted waist circumference	EFO_0007789	1	7	7		93.8
adiponectin measurement	EFO_0004502	2	2	2		83.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	11		97
BMI-adjusted waist-hip ratio	EFO_0007788	16		96.9
waist circumference	EFO_0004342	7		93.9
BMI-adjusted waist circumference	EFO_0007789	7		93.8
adiponectin measurement	EFO_0004502	2		83.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell projection
Ciliopathy
Cilium biogenesis/degradation
Complete proteome
Cytoplasm
Cytoskeleton
Glycoprotein
Joubert syndrome
Meckel syndrome

GWAS Trait Find Similar Targets

No Header	No Header
adiponectin measurement
alkaline phosphatase measurement
apolipoprotein A 1 measurement
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
high density lipoprotein cholesterol measurement
hip circumference
leukocyte count
low density lipoprotein cholesterol measurement
lymphocyte count

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
growth/size/body region phenotype
limbs/digits/tail phenotype
nervous system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tectonic family member 2	VGNC:5616	100615573
Dog	tectonic family member 2	VGNC:47214	477445
Horse	tectonic family member 2	VGNC:23968	100630826
Cow	tectonic family member 2	VGNC:35709	100847961
Pig	tectonic family member 2		100153315

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tectonic family member 2
Dog	tectonic family member 2
Horse	tectonic family member 2
Cow	tectonic family member 2
Pig	tectonic family member 2

Publication Statistics

PubMed Score 10.46

PubMed score by year

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PubTator Score 3.94

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title