Protein Summary
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity). This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- ENST00000303372
- ENSP00000304941
- ENSG00000168778
- ENST00000426174
- ENSP00000395171
- C12orf38
- TECT2
- MKS8
- TECT2
- JBTS24
- C12orf38
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cellular component | 0.76 | ||
histone modification site profile | 0.75 | ||
cell line | 0.61 | ||
cell type or tissue | 0.6 | ||
small molecule perturbation | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.46 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 137 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.46 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 137 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (221)
TMEM231
Novelty: 0.17100188
p_int: 0.99999996
p_ni: 4e-8
Score: 0.943
Data Source: BioPlex,STRINGDB
PIGB
Family: Enzyme
Novelty: 0.05237713
p_int: 0.999977147
p_ni: 0.000022846
p_wrong: 7e-9
Data Source: BioPlex
ALG12
Family: Enzyme
Novelty: 0.03785588
p_int: 0.999831275
p_ni: 0.000168725
Data Source: BioPlex
GLRB
Family: IC
Novelty: 0.01721113
p_int: 0.999803439
p_ni: 0.000196561
p_wrong: 1e-9
Data Source: BioPlex
JMJD8
Novelty: 0.31175159
p_int: 0.999483461
p_ni: 0.000514451
p_wrong: 0.000002088
Data Source: BioPlex
NXPE3
Novelty: 1.5063521
p_int: 0.999427312
p_ni: 0.000568913
p_wrong: 0.000003775
Data Source: BioPlex
TMEM8A
Novelty: 0.15724279
p_int: 0.999413191
p_ni: 0.000113393
p_wrong: 0.000473416
Data Source: BioPlex
HLA-DMB
Novelty: 0.02289537
p_int: 0.998623601
p_ni: 0.000133386
p_wrong: 0.001243013
Score: 0.307
Data Source: BioPlex,STRINGDB
GRID1
Family: IC
Novelty: 0.05041468
p_int: 0.997981417
p_ni: 0.001969736
p_wrong: 0.000048847
Data Source: BioPlex
JAG2
Novelty: 0.00176158
p_int: 0.997757763
p_ni: 0.002242216
p_wrong: 2.1e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (18)
Reactome (3)
WikiPathways (15)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Anchoring of the basal body to the plasma membrane | ||||
Reactome | Cilium Assembly | ||||
Reactome | Organelle biogenesis and maintenance | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Anchoring of the basal body to the plasma membrane | ||||
Cilium Assembly | ||||
Organelle biogenesis and maintenance | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
waist-hip ratio | 1 | 11 | 11 | 97 | |||||
BMI-adjusted waist-hip ratio | 6 | 12 | 16 | 96.9 | |||||
waist circumference | 1 | 7 | 7 | 93.9 | |||||
BMI-adjusted waist circumference | 1 | 7 | 7 | 93.8 | |||||
adiponectin measurement | 2 | 2 | 2 | 83.6 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
waist-hip ratio | 11 | 97 | |||||
BMI-adjusted waist-hip ratio | 16 | 96.9 | |||||
waist circumference | 7 | 93.9 | |||||
BMI-adjusted waist circumference | 7 | 93.8 | |||||
adiponectin measurement | 2 | 83.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | tectonic family member 2 | VGNC:5616 | 100615573 | |||||
Dog | tectonic family member 2 | VGNC:47214 | 477445 | |||||
Horse | tectonic family member 2 | VGNC:23968 | 100630826 | |||||
Cow | tectonic family member 2 | VGNC:35709 | 100847961 | |||||
Pig | tectonic family member 2 | 100153315 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | tectonic family member 2 | |||||
Dog | tectonic family member 2 | |||||
Horse | tectonic family member 2 | |||||
Cow | tectonic family member 2 | |||||
Pig | tectonic family member 2 | |||||
Publication Statistics
PubMed Score 10.46
PubMed score by year
PubTator Score 3.94
PubTator score by year
Related Publications
Text Mined References (8)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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