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Tbio
TCTA
T-cell leukemia translocation-altered gene protein

Protein Summary
Description
May be required for cellular fusion during osteoclastogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273590
  • ENSP00000273590
  • ENSG00000145022
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
cell type or tissue
0.75
transcription factor perturbation
0.68
small molecule perturbation
0.66
histone modification site profile
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.25   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.25   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
GATM
Tbio
Family:  Enzyme
Novelty:  0.00340356
Score:  0.726
Data Source:  STRINGDB
DLG5
Tbio
Novelty:  0.01630244
Score:  0.666
Data Source:  STRINGDB
PCDH17
Tbio
Novelty:  0.03341603
Score:  0.658
Data Source:  STRINGDB
DLG3
Tbio
Novelty:  0.01196565
Score:  0.645
Data Source:  STRINGDB
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
Score:  0.634
Data Source:  STRINGDB
TMEM11
Tbio
Novelty:  0.00067837
Score:  0.627
Data Source:  STRINGDB
SSB
Tbio
Novelty:  0.00230478
Score:  0.624
Data Source:  STRINGDB
GCAT
Tbio
Family:  Enzyme
Novelty:  0.00503538
Score:  0.617
Data Source:  STRINGDB
FANK1
Tbio
Novelty:  0.12389783
Score:  0.612
Data Source:  STRINGDB
NPB
Tdark
Novelty:  0.00936692
Score:  0.584
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
4
12
5
6.5
95.2
self reported educational attainment
5
4
4
1
91.8
household income
1
4
4
90.1
cognitive function measurement
2
1
2
85.2
red blood cell distribution width
3
2
3
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
6.5
95.2
self reported educational attainment
4
1
91.8
household income
4
90.1
cognitive function measurement
2
85.2
red blood cell distribution width
3
82.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T cell leukemia translocation altered
VGNC:2601
460368
Mouse
MGI:1918829
102791
Rat
RGD:1359333
306587
Dog
T-cell leukemia translocation altered
608826
Horse
T-cell leukemia translocation altered
100053301
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T cell leukemia translocation altered
Mouse
Rat
Dog
T-cell leukemia translocation altered
Horse
T-cell leukemia translocation altered
Publication Statistics
PubMed Score 17.25
PubMed score by year
PubTator Score 37.37
PubTator score by year
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Related Publications
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PMID
Year
Title