Pharos : Target Details

Tbio

Protein Summary

Description

May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.

Uniprot Accession IDs

Gene Name

TCP10L

Ensembl ID

ENST00000300258
ENSP00000300258
ENSG00000242220

Symbol

PRED77
C21orf77
TCP10A-1
TCP10A-2

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.61

microRNA	0.59

cell type or tissue	0.53

molecular function	0.53

biological process	0.52

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.73 (req: < 5)

View Publications

Gene RIFs: 5 (req: <= 3)

View Gene RIFs

Antibodies: 62 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.73 (req: >= 5)

Gene RIFs: 5 (req: > 3)

Antibodies: 62 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (49)

Explore Interacting Targets

1 – 10 of 49

See Interactions on String-DB

GRIPAP1

Tbio

Novelty: 0.09814766

p_int: 0.999999994

p_ni: 6e-9

Score: 0.258

Data Source: BioPlex,STRINGDB

PPP1R21

Tdark

Family: Enzyme

Novelty: 0.33099657

p_int: 0.999999969

p_ni: 2.7e-8

p_wrong: 4e-9

Data Source: BioPlex

TBCK

Tbio

Family: Kinase

Novelty: 0.08568145

p_int: 0.999999905

p_ni: 1.1e-8

p_wrong: 8.4e-8

Score: 0.188

Data Source: BioPlex,STRINGDB

KIF20B

Tbio

Novelty: 0.0465712

p_int: 0.999999472

p_ni: 5.28e-7

Data Source: BioPlex

CHMP5

Tbio

Novelty: 0.03378716

p_int: 0.999996123

p_ni: 5.2e-8

p_wrong: 0.000003825

Score: 0.258

Data Source: BioPlex,STRINGDB

CRYZL1

Tbio

Family: Enzyme

Novelty: 0.04435286

p_int: 0.999995187

p_ni: 0.00000479

p_wrong: 2.3e-8

Data Source: BioPlex

RNF20

Tbio

Family: Enzyme

Novelty: 0.01238827

p_int: 0.999991612

p_ni: 0.000008388

Data Source: BioPlex

SH3KBP1

Tbio

Family: Enzyme

Novelty: 0.01454593

p_int: 0.999989709

p_ni: 0.000010275

p_wrong: 1.6e-8

Data Source: BioPlex

FBXO28

Tbio

Novelty: 0.10548865

p_int: 0.999983914

p_ni: 0.000016086

Data Source: BioPlex

PICK1

Tbio

Novelty: 0.0058265

p_int: 0.999977205

p_ni: 0.000022777

p_wrong: 1.8e-8

Data Source: BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (4)

Components (1)

Processes (1)

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Items per page:

1 – 4 of 4

GO Term	Evidence	Assigned by
protein self-association	Inferred from Direct Assay (IDA)	UniProtKB

repressing transcription factor binding	Inferred from Direct Assay (IDA)	UniProtKB

transcription corepressor activity	Inferred from Direct Assay (IDA)	UniProtKB

identical protein binding	Inferred from Physical Interaction (IPI)	IntAct

Disease Associations ()

No disease associations found

GWAS Traits (2)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
serum gamma-glutamyl transferase measurement	EFO_0004532	1	1	1	35

intraocular pressure measurement	EFO_0004695	1	1	1	17.8

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
serum gamma-glutamyl transferase measurement	EFO_0004532	1	35

intraocular pressure measurement	EFO_0004695	1	17.8

Beta Count

Odds Ratio

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UniProt Keyword

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No Header	No Header
Coiled coil

Complete proteome

Nucleus

Polymorphism

Reference proteome

Repressor

Transcription

Transcription regulation

Tumor suppressor

GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (1)

1 – 1 of 1

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	t-complex 10 like		470075

Species	Name	OMA	EggNOG	Inparanoid
Chimp	t-complex 10 like

Publication Statistics

PubMed Score 6.73

PubMed score by year

PubTator Score 4.08

PubTator score by year

Related Publications

Text Mined References (16)

GeneRif Annotations (5)

Items per page:

0 of 0

PMID	Year	Title