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Tbio
TCP10L
T-complex protein 10A homolog 1

Protein Summary
Description
May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300258
  • ENSP00000300258
  • ENSG00000242220

Symbol
  • PRED77
  • C21orf77
  • TCP10A-1
  • TCP10A-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.61
microRNA
0.59
cell type or tissue
0.53
molecular function
0.53
biological process
0.52


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.73   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.73   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
GRIPAP1
Tbio
Novelty:  0.09814766
p_int:  0.999999994
p_ni:  6e-9
Score:  0.258
Data Source:  BioPlex,STRINGDB
PPP1R21
Tdark
Family:  Enzyme
Novelty:  0.33099657
p_int:  0.999999969
p_ni:  2.7e-8
p_wrong:  4e-9
Data Source:  BioPlex
TBCK
Tbio
Family:  Kinase
Novelty:  0.08568145
p_int:  0.999999905
p_ni:  1.1e-8
p_wrong:  8.4e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
KIF20B
Tbio
Novelty:  0.0465712
p_int:  0.999999472
p_ni:  5.28e-7
Data Source:  BioPlex
CHMP5
Tbio
Novelty:  0.03378716
p_int:  0.999996123
p_ni:  5.2e-8
p_wrong:  0.000003825
Score:  0.258
Data Source:  BioPlex,STRINGDB
CRYZL1
Tbio
Family:  Enzyme
Novelty:  0.04435286
p_int:  0.999995187
p_ni:  0.00000479
p_wrong:  2.3e-8
Data Source:  BioPlex
RNF20
Tbio
Family:  Enzyme
Novelty:  0.01238827
p_int:  0.999991612
p_ni:  0.000008388
Data Source:  BioPlex
SH3KBP1
Tbio
Family:  Enzyme
Novelty:  0.01454593
p_int:  0.999989709
p_ni:  0.000010275
p_wrong:  1.6e-8
Data Source:  BioPlex
FBXO28
Tbio
Novelty:  0.10548865
p_int:  0.999983914
p_ni:  0.000016086
Data Source:  BioPlex
PICK1
Tbio
Novelty:  0.0058265
p_int:  0.999977205
p_ni:  0.000022777
p_wrong:  1.8e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
35
intraocular pressure measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
35
intraocular pressure measurement
1
17.8
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
t-complex 10 like
470075
Species
Name
OMA
EggNOG
Inparanoid
Chimp
t-complex 10 like
Publication Statistics
PubMed Score 6.73
PubMed score by year
PubTator Score 4.08
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title