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Tbio
TCL1B
T-cell leukemia/lymphoma protein 1B

Protein Summary
Description
Enhances the phosphorylation and activation of AKT1 and AKT2.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340722
  • ENSP00000343223
  • ENSG00000213231

Symbol
  • TCL1
  • TML1
  • SYN-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.52
cellular component
0.45
chemical
0.41
cell line
0.38
microRNA
0.36


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.55   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.55   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
MAGI3
Tbio
Family:  Enzyme
Novelty:  0.03968945
p_int:  0.999999603
p_ni:  3.96e-7
p_wrong:  1e-9
Score:  0.165
Data Source:  BioPlex,STRINGDB
HPS5
Tbio
Novelty:  0.05155851
p_int:  0.999998977
p_ni:  0.000001023
Score:  0.226
Data Source:  BioPlex,STRINGDB
MED13
Tbio
Family:  Enzyme
Novelty:  0.02090708
p_int:  0.999881934
p_ni:  0.000118042
p_wrong:  2.4e-8
Score:  0.305
Data Source:  BioPlex,STRINGDB
ARFGEF1
Tbio
Novelty:  0.16148196
p_int:  0.999592228
p_ni:  0.000407772
Score:  0.179
Data Source:  BioPlex,STRINGDB
MED22
Tbio
Family:  Enzyme
Novelty:  0.07630387
p_int:  0.998664922
p_ni:  0.000672288
p_wrong:  0.00066279
Score:  0.305
Data Source:  BioPlex,STRINGDB
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
p_int:  0.998050429
p_ni:  0.001949571
Data Source:  BioPlex
MED24
Tbio
Family:  Enzyme
Novelty:  0.05466084
p_int:  0.997613953
p_ni:  0.002386045
p_wrong:  2e-9
Score:  0.315
Data Source:  BioPlex,STRINGDB
MED10
Tdark
Family:  Enzyme
Novelty:  0.02988632
p_int:  0.996449055
p_ni:  0.003550867
p_wrong:  7.8e-8
Score:  0.305
Data Source:  BioPlex,STRINGDB
MED17
Tbio
Family:  Enzyme
Novelty:  0.02984503
p_int:  0.994868122
p_ni:  0.005131878
Score:  0.203
Data Source:  BioPlex,STRINGDB
MED8
Tbio
Family:  Enzyme
Novelty:  0.06648307
p_int:  0.992720148
p_ni:  0.006655551
p_wrong:  0.000624301
Score:  0.305
Data Source:  BioPlex,STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
4
4
4
1.6
98
platelet crit
1
1
1
66.8
platelet count
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
4
1.6
98
platelet crit
1
66.8
platelet count
1
8.3
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
T-cell leukemia/lymphoma 1B
703241
Mouse
MGI:1351601
27379
Cow
T-cell leukemia/lymphoma 1B
100848382
Pig
T-cell leukemia/lymphoma 1B
100525932
Species
Name
OMA
EggNOG
Inparanoid
Macaque
T-cell leukemia/lymphoma 1B
Mouse
Cow
T-cell leukemia/lymphoma 1B
Pig
T-cell leukemia/lymphoma 1B
Publication Statistics
PubMed Score 154.55
PubMed score by year
PubTator Score 7.42
PubTator score by year
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Related Publications
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PMID
Year
Title