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Tbio
TCL1A
T-cell leukemia/lymphoma protein 1A

Protein Summary
Description
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402399
  • ENSP00000385036
  • ENSG00000100721
  • ENST00000554012
  • ENSP00000451506
  • ENST00000555202
  • ENSP00000450496
  • ENST00000556450
  • ENSP00000450701

Symbol
  • TCL1
  • TCL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
kinase perturbation
0.88
gene perturbation
0.76
virus perturbation
0.68
biological term
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.06   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 369   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.06   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
DNMT3B
Tchem
Family:  Epigenetic
Novelty:  0.00118766
p_int:  1
Score:  0.369
Data Source:  BioPlex,STRINGDB
DNMT3A
Tclin
Family:  Epigenetic
Novelty:  0.00085974
p_int:  0.999999991
p_ni:  8e-9
Score:  0.531
Data Source:  BioPlex,STRINGDB
TXLNG
Tbio
Novelty:  0.08274423
p_int:  0.999998951
p_ni:  0.000001049
Data Source:  BioPlex
PNPT1
Tbio
Family:  Enzyme
Novelty:  0.00339969
p_int:  0.999993315
p_ni:  0.000006685
Score:  0.292
Data Source:  BioPlex,STRINGDB
CALCOCO2
Tbio
Novelty:  0.01456844
p_int:  0.99994422
p_ni:  0.00005578
Data Source:  BioPlex
R3HDM1
Tdark
Novelty:  0.19586369
p_int:  0.998589643
p_ni:  0.000044351
p_wrong:  0.001366006
Data Source:  BioPlex
TXLNA
Tbio
Novelty:  0.02549959
p_int:  0.997329164
p_ni:  0.002670836
Data Source:  BioPlex
KLHL24
Tbio
Novelty:  0.04032749
p_int:  0.968380539
p_ni:  0.03161946
Data Source:  BioPlex
PGP
Tbio
Family:  Enzyme
Novelty:  0.0225528
p_int:  0.964813355
p_ni:  0.035186645
Data Source:  BioPlex
METAP1
Tchem
Family:  Enzyme
Novelty:  0.01816253
p_int:  0.96398099
p_ni:  0.035996046
p_wrong:  0.000022965
Data Source:  BioPlex
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
4
4
4
1.6
98
platelet crit
1
1
1
66.8
platelet count
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
4
1.6
98
platelet crit
1
66.8
platelet count
1
8.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T-cell leukemia/lymphoma 1A
741380
Macaque
T cell leukemia/lymphoma 1A [Source:HGNC Symbol;Acc:HGNC:11648]
Mouse
MGI:1097166
21432
Rat
RGD:1594686
690575
Cow
T-cell leukemia/lymphoma 1A
506540
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T-cell leukemia/lymphoma 1A
Macaque
T cell leukemia/lymphoma 1A [Source:HGNC Symbol;Acc:HGNC:11648]
Mouse
Rat
Cow
T-cell leukemia/lymphoma 1A
Publication Statistics
PubMed Score 172.06
PubMed score by year
PubTator Score 161.17
PubTator score by year
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Related Publications
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PMID
Year
Title