Protein Summary
Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. The protein encoded by this gene forms crosslinked complexes with itself and keratin intermediate filaments to provide mechanical strength to the hair follicle inner root sheath. The encoded protein also is important for structural integrity of the filiform papillae of the tongue. Defects in this gene are a cause of uncombable hair syndrome. [provided by RefSeq, Feb 2017]
- ENST00000368804
- ENSP00000357794
- ENSG00000159450
- ENST00000614923
- ENSP00000480484
- THH
- THL
- TRHY
- THH
- THL
- TRHY
- UHS3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.73 | ||
cell type or tissue | 0.64 | ||
tissue | 0.62 | ||
microRNA | 0.61 | ||
tissue sample | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 296.62 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 31 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 296.62 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 31 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (104)
OAZ3
Family: Enzyme
Novelty: 0.02374168
p_int: 0.999988637
p_ni: 0.000002483
p_wrong: 0.000008881
Score: 0.189
Data Source: BioPlex,STRINGDB
CCND1
Novelty: 0.0001186
p_int: 0.999778397
p_ni: 0.00004013
p_wrong: 0.000181473
Score: 0.233
Data Source: BioPlex,STRINGDB
NSMAF
Novelty: 0.08595515
p_int: 0.961598369
p_ni: 0.000070362
p_wrong: 0.03833127
Score: 0.219
Data Source: BioPlex,STRINGDB
ANKH
Novelty: 0.00995443
p_int: 0.778172143
p_ni: 0.000012712
p_wrong: 0.221815145
Data Source: BioPlex
TBC1D14
Novelty: 0.25089884
p_int: 0.767642715
p_ni: 0.000003937
p_wrong: 0.232353348
Score: 0.188
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 4 | 7 | 9 | 98.4 | |||||
hair shape measurement | 1 | 2 | 2 | 95.6 | |||||
4 | 3 | 4 | 1.1 | 93.1 | |||||
6 | 4 | 0 | 1.2 | 91.4 | |||||
age at onset | 2 | 2 | 2 | 1.3 | 85.7 | ||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
vitamin D measurement | 9 | 98.4 | |||||
hair shape measurement | 2 | 95.6 | |||||
4 | 1.1 | 93.1 | |||||
0 | 1.2 | 91.4 | |||||
age at onset | 2 | 1.3 | 85.7 | ||||
Find similar targets by:
IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:2177944 | 99681 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Publication Statistics
PubMed Score 296.62
PubMed score by year
PubTator Score 31.55
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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