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Tbio
TCHH
Trichohyalin

Protein Summary
Description
Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. The protein encoded by this gene forms crosslinked complexes with itself and keratin intermediate filaments to provide mechanical strength to the hair follicle inner root sheath. The encoded protein also is important for structural integrity of the filiform papillae of the tongue. Defects in this gene are a cause of uncombable hair syndrome. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368804
  • ENSP00000357794
  • ENSG00000159450
  • ENST00000614923
  • ENSP00000480484

Symbol
  • THH
  • THL
  • TRHY
  • THH
  • THL
  • TRHY
  • UHS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell type or tissue
0.64
tissue
0.62
microRNA
0.61
tissue sample
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.62   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.62   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (104)
OAZ3
Tbio
Family:  Enzyme
Novelty:  0.02374168
p_int:  0.999988637
p_ni:  0.000002483
p_wrong:  0.000008881
Score:  0.189
Data Source:  BioPlex,STRINGDB
CCND1
Tchem
Novelty:  0.0001186
p_int:  0.999778397
p_ni:  0.00004013
p_wrong:  0.000181473
Score:  0.233
Data Source:  BioPlex,STRINGDB
NSMAF
Tbio
Novelty:  0.08595515
p_int:  0.961598369
p_ni:  0.000070362
p_wrong:  0.03833127
Score:  0.219
Data Source:  BioPlex,STRINGDB
ANKH
Tbio
Novelty:  0.00995443
p_int:  0.778172143
p_ni:  0.000012712
p_wrong:  0.221815145
Data Source:  BioPlex
TBC1D14
Tbio
Novelty:  0.25089884
p_int:  0.767642715
p_ni:  0.000003937
p_wrong:  0.232353348
Score:  0.188
Data Source:  BioPlex,STRINGDB
IVL
Tbio
Novelty:  0.00147892
Score:  0.974
Data Source:  STRINGDB
LOR
Tbio
Novelty:  0.0033781
Score:  0.974
Data Source:  STRINGDB
SPRR1A
Tbio
Novelty:  0.04328986
Score:  0.966
Data Source:  STRINGDB
SPRR1B
Tbio
Novelty:  0.0320028
Score:  0.958
Data Source:  STRINGDB
SPRR3
Tbio
Novelty:  0.0241484
Score:  0.956
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
4
7
9
98.4
hair shape measurement
1
2
2
95.6
4
3
4
1.1
93.1
6
4
0
1.2
91.4
age at onset
2
2
2
1.3
85.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
9
98.4
hair shape measurement
2
95.6
4
1.1
93.1
0
1.2
91.4
age at onset
2
1.3
85.7
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 296.62
PubMed score by year
PubTator Score 31.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title