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Tbio
TCF4
Transcription factor 4

Protein Summary
Description
Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354452
  • ENSP00000346440
  • ENSG00000196628
  • ENST00000356073
  • ENSP00000348374
  • ENST00000457482
  • ENSP00000409447
  • ENST00000537578
  • ENSP00000440731
  • ENST00000537856
  • ENSP00000439827
  • ENST00000540999
  • ENSP00000445202
  • ENST00000543082
  • ENSP00000439656
  • ENST00000544241
  • ENSP00000441562
  • ENST00000561831
  • ENSP00000457765
  • ENST00000561992
  • ENSP00000455179
  • ENST00000564228
  • ENSP00000455261
  • ENST00000564999
  • ENSP00000457649
  • ENST00000565018
  • ENSP00000455984
  • ENST00000566279
  • ENSP00000456125
  • ENST00000566286
  • ENSP00000455418
  • ENST00000567880
  • ENSP00000454366
  • ENST00000568673
  • ENSP00000455135
  • ENST00000570177
  • ENSP00000454647
  • ENST00000570287
  • ENSP00000455763
  • ENST00000616053
  • ENSP00000478549
  • ENST00000626584
  • ENSP00000486072
  • ENST00000629387
  • ENSP00000486670
  • ENST00000636400
  • ENSP00000490006

Symbol
  • BHLHB19
  • ITF2
  • SEF2
  • E2-2
  • ITF2
  • PTHS
  • SEF2
  • FECD3
  • ITF-2
  • SEF-2
  • TCF-4
  • SEF2-1
  • SEF2-1A
  • SEF2-1B
  • SEF2-1D
  • bHLHb19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.98
disease perturbation
0.97
transcription factor perturbation
0.97
small molecule perturbation
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.74   (req: < 5)
Gene RIFs: 113   (req: <= 3)
Antibodies: 349   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.74   (req: >= 5)
Gene RIFs: 113   (req: > 3)
Antibodies: 349   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0