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Tbio
TCF3
Transcription factor E2-alpha

Protein Summary
Description
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region. This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or dimin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262965
  • ENSP00000262965
  • ENSG00000071564
  • ENST00000395423
  • ENSP00000378813
  • ENST00000588136
  • ENSP00000468487
  • ENST00000611869
  • ENSP00000480564

Symbol
  • BHLHB21
  • E2A
  • ITF1
  • E2A
  • E47
  • p75
  • AGM8
  • ITF1
  • VDIR
  • TCF-3
  • bHLHb21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.98
disease perturbation
0.97
PubMedID
0.97
hub protein
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 958.37   (req: < 5)
Gene RIFs: 94   (req: <= 3)
Antibodies: 533   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 958.37   (req: >= 5)
Gene RIFs: 94   (req: > 3)
Antibodies: 533   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0