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Tbio
TCEAL1
Transcription elongation factor A protein-like 1

Protein Summary
Description
May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly. This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple trans ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372624
  • ENSP00000361707
  • ENSG00000172465
  • ENST00000372625
  • ENSP00000361708
  • ENST00000372626
  • ENSP00000361709

Symbol
  • SIIR
  • p21
  • SIIR
  • WEX9
  • pp21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
virus perturbation
0.83
kinase perturbation
0.71
tissue sample
0.68
PubMedID
0.59


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.5   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.5   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
KDM3A
Tchem
Family:  Epigenetic
Novelty:  0.0101705
p_int:  1
Score:  0.186
Data Source:  BioPlex,STRINGDB
UHRF1
Tbio
Family:  Epigenetic
Novelty:  0.00482565
p_int:  0.999999134
p_ni:  8.65e-7
p_wrong:  1e-9
Data Source:  BioPlex
EYA3
Tbio
Novelty:  0.05588286
p_int:  0.99999567
p_ni:  0.000004304
p_wrong:  2.7e-8
Score:  0.242
Data Source:  BioPlex,STRINGDB
POGK
Tbio
Novelty:  0.17276635
p_int:  0.999985902
p_ni:  0.000003481
p_wrong:  0.000010617
Score:  0.173
Data Source:  BioPlex,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
p_int:  0.999948156
p_ni:  0.000051844
Data Source:  BioPlex
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.999939541
p_ni:  0.000046405
p_wrong:  0.000014054
Score:  0.16
Data Source:  BioPlex,STRINGDB
SCNM1
Tbio
Novelty:  0.19700548
p_int:  0.999795508
p_ni:  0.000204492
Data Source:  BioPlex
FAF1
Tbio
Novelty:  0.01526275
p_int:  0.99954722
p_ni:  0.00045278
Score:  0.173
Data Source:  BioPlex,STRINGDB
TDP2
Tchem
Family:  Enzyme
Novelty:  0.01104303
p_int:  0.998452818
p_ni:  0.001435063
p_wrong:  0.000112119
Score:  0.181
Data Source:  BioPlex,STRINGDB
ZUP1
Tbio
Family:  Enzyme
Novelty:  0.21515695
p_int:  0.998224019
p_ni:  9.4e-8
p_wrong:  0.001775888
Score:  0.617
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
47.7
lymphocyte percentage of leukocytes
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
47.7
lymphocyte percentage of leukocytes
1
12.1
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transcription elongation factor A like 1
696826
Mouse
MGI:2385317
237052
Rat
RGD:1549724
302593
Dog
transcription elongation factor A like 1
VGNC:49659
481000
Horse
transcription elongation factor A like 1
VGNC:49279
100054457
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transcription elongation factor A like 1
Mouse
Rat
Dog
transcription elongation factor A like 1
Horse
transcription elongation factor A like 1
Publication Statistics
PubMed Score 55.50
PubMed score by year
PubTator Score 18.06
PubTator score by year
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Related Publications
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PMID
Year
Title