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Tbio
TCEA1
Transcription elongation factor A protein 1

Protein Summary
Description
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396401
  • ENSP00000395483
  • ENSG00000187735
  • ENST00000521604
  • ENSP00000428426

Symbol
  • GTF2S
  • TFIIS
  • SII
  • TCEA
  • TF2S
  • GTF2S
  • TFIIS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.97
protein domain
0.92
PubMedID
0.87
transcription factor binding site profile
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 441.99   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 441.99   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0