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Tbio
TCAF2
TRPM8 channel-associated factor 2

Protein Summary
Description
Isoform 2: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357344
  • ENSP00000349902
  • ENSG00000170379
  • ENST00000411935
  • ENSP00000389100
  • ENST00000425618
  • ENSP00000441099
  • ENST00000441159
  • ENSP00000404265
  • ENST00000444908
  • ENSP00000412724
  • ENST00000643242
  • ENSP00000495809

Symbol
  • FAM115C
  • FAM139A
  • GATD9
  • FAM115C
  • FAM139A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.61
tissue sample
0.58
transcription factor
0.56
biological process
0.51
microRNA
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.18   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.18   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0