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Tbio
TCAF2
TRPM8 channel-associated factor 2

Protein Summary
Description
Isoform 2: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357344
  • ENSP00000349902
  • ENSG00000170379
  • ENST00000411935
  • ENSP00000389100
  • ENST00000425618
  • ENSP00000441099
  • ENST00000441159
  • ENSP00000404265
  • ENST00000444908
  • ENSP00000412724
  • ENST00000643242
  • ENSP00000495809

Symbol
  • FAM115C
  • FAM139A
  • GATD9
  • FAM115C
  • FAM139A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.61
tissue sample
0.58
transcription factor
0.56
biological process
0.51
microRNA
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.49   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.49   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
MADCAM1
Tbio
Novelty:  0.00325843
p_int:  0.999999341
p_ni:  6.59e-7
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.999993139
p_ni:  0.000006861
Data Source:  BioPlex
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.999992636
p_ni:  0.000007364
Data Source:  BioPlex
CD44
Tbio
Novelty:  0.00011321
p_int:  0.999976722
p_ni:  0.000023278
Data Source:  BioPlex
CD27
Tbio
Novelty:  0.00090508
p_int:  0.999946877
p_ni:  0.00005307
p_wrong:  5.4e-8
Data Source:  BioPlex
NPPB
Tbio
Novelty:  0.00024947
p_int:  0.999927397
p_ni:  0.000072603
Data Source:  BioPlex
TMEM108
Tbio
Novelty:  0.08687599
p_int:  0.999913591
p_ni:  0.000086408
Data Source:  BioPlex
NOG
Tbio
Novelty:  0.0010373
p_int:  0.999758773
p_ni:  0.000241227
Data Source:  BioPlex
RELL1
Tbio
Novelty:  0.28949625
p_int:  0.999735825
p_ni:  0.000264175
Data Source:  BioPlex
ODAPH
Tbio
Novelty:  0.20386223
p_int:  0.999604617
p_ni:  0.000395285
p_wrong:  9.8e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TRPM8 channel associated factor 2
VGNC:8782
463810
Macaque
TRPM8 channel associated factor 2
707579
Mouse
MGI:2385258
232748
Rat
RGD:1591778
680422
Cow
TRPM8 channel associated factor 2
510320
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TRPM8 channel associated factor 2
Macaque
TRPM8 channel associated factor 2
Mouse
Rat
Cow
TRPM8 channel associated factor 2
Publication Statistics
PubMed Score 3.49
PubMed score by year
PubTator Score 0.81
PubTator score by year
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Related Publications
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PMID
Year
Title