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Tbio
TCAF1
TRPM8 channel-associated factor 1

Protein Summary
Description
Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355951
  • ENSP00000348220
  • ENSG00000198420
  • ENST00000479870
  • ENSP00000419235

Symbol
  • FAM115A
  • KIAA0738
  • FAM115A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
tissue
0.62
microRNA
0.59
PubMedID
0.59
virus perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.54   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.54   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
UBXN1
Tbio
Novelty:  0.10675958
p_int:  0.989219943
p_ni:  0.010780057
Score:  0.519
Data Source:  BioPlex,STRINGDB
PWP1
Tbio
Novelty:  0.07040539
p_int:  0.920154287
p_ni:  0.079845713
Score:  0.346
Data Source:  BioPlex,STRINGDB
RSPH6A
Tdark
Novelty:  0.03734897
p_int:  0.917845864
p_ni:  0.082154137
Data Source:  BioPlex
LRP1
Tbio
Novelty:  0.00200788
p_int:  0.904866506
p_ni:  0.095133494
Data Source:  BioPlex
PEG10
Tbio
Novelty:  0.00478545
p_int:  0.904776616
p_ni:  0.095223384
Score:  0.243
Data Source:  BioPlex,STRINGDB
SREK1IP1
Tdark
Novelty:  1.39429464
p_int:  0.824913847
p_ni:  0.175086153
Data Source:  BioPlex
TGDS
Tbio
Family:  Enzyme
Novelty:  0.01813871
p_int:  0.818628686
p_ni:  0.181371314
Score:  0.332
Data Source:  BioPlex,STRINGDB
CLEC14A
Tbio
Novelty:  0.03231666
p_int:  0.815390269
p_ni:  0.184609731
Score:  0.197
Data Source:  BioPlex,STRINGDB
TRPM8
Tclin
Family:  IC
Novelty:  0.00153949
Score:  0.747
Data Source:  STRINGDB
CTAGE6
Tdark
Novelty:  52
Score:  0.653
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TRPM8 channel associated factor 1
VGNC:8781
463811
Macaque
TRPM8 channel associated factor 1
705151
Mouse
MGI:1914665
77574
Rat
RGD:1565474
362353
Pig
TRPM8 channel-associated factor 1
100519808
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TRPM8 channel associated factor 1
Macaque
TRPM8 channel associated factor 1
Mouse
Rat
Pig
TRPM8 channel-associated factor 1
Publication Statistics
PubMed Score 3.54
PubMed score by year
PubTator Score 0.79
PubTator score by year
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Related Publications
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PMID
Year
Title