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Tbio
TBX5
T-box transcription factor TBX5

Protein Summary
Description
DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation (PubMed:25725155, PubMed:25963046, PubMed:29174768, PubMed:26917986, PubMed:27035640, PubMed:8988164). Binds to the core DNA motif of NPPA promoter (PubMed:26926761). This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310346
  • ENSP00000309913
  • ENSG00000089225
  • ENST00000349716
  • ENSP00000337723
  • ENST00000405440
  • ENSP00000384152
  • ENST00000526441
  • ENSP00000433292

Symbol
  • HOS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
co-expressed gene
0.97
trait
0.75
cell line
0.7
disease
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 385.11   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 385.11   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (140)
NKX2-5
Tbio
Family:  TF
Novelty:  0.00125993
Score:  0.998
Data Source:  STRINGDB
GATA4
Tbio
Family:  TF
Novelty:  0.00094282
Score:  0.985
Data Source:  STRINGDB
WWTR1
Tbio
Novelty:  0.00431186
Score:  0.975
Data Source:  Reactome,STRINGDB
NPPA
Tchem
Novelty:  0.00046693
Score:  0.966
Data Source:  STRINGDB
SALL4
Tbio
Family:  TF
Novelty:  0.00354374
Score:  0.943
Data Source:  STRINGDB
KAT2B
Tchem
Family:  Epigenetic
Novelty:  0.00172126
Score:  0.918
Data Source:  Reactome,STRINGDB
SMARCA4
Tchem
Family:  Epigenetic
Novelty:  0.00112496
Score:  0.883
Data Source:  STRINGDB
SMARCD3
Tbio
Novelty:  0.03423481
Score:  0.867
Data Source:  STRINGDB
MEF2C
Tbio
Family:  TF
Novelty:  0.00232724
Score:  0.862
Data Source:  STRINGDB
NKX2-3
Tbio
Family:  TF
Novelty:  0.02138156
Score:  0.855
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Muscle contraction
Reactome
Physiological factors
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Gene expression (Transcription)
Generic Transcription Pathway
Muscle contraction
Physiological factors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (39)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
2
3
95
7.4
93.9
PR interval
4
4
0
3.2
88.3
5
1
0
1.1
84.4
QT interval
1
1
0
7.4
57.8
heart rate
1
1
0
7.4
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
95
7.4
93.9
PR interval
0
3.2
88.3
0
1.1
84.4
QT interval
0
7.4
57.8
heart rate
0
7.4
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T-box 5
VGNC:5614
452276
Macaque
T-box 5
713550
Mouse
MGI:102541
21388
Rat
RGD:1305702
304514
Dog
T-box 5
VGNC:47176
491447
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T-box 5
Macaque
T-box 5
Mouse
Rat
Dog
T-box 5
Publication Statistics
PubMed Score 385.11
PubMed score by year
PubTator Score 190.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title