TBX21
T-box transcription factor TBX21
Protein Summary
Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931). Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648). Inhibits the Th17 cell lineage commitment by ...more
- ENST00000177694
- ENSP00000177694
- ENSG00000073861
- TBET
- TBLYM
- TBET
- T-PET
- T-bet
- TBLYM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.92 | ||
biological term | 0.68 | ||
gene perturbation | 0.65 | ||
pathway | 0.64 | ||
tissue sample | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1044.7 (req: < 5)
Gene RIFs: 173 (req: <= 3)
Antibodies: 634 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1044.7 (req: >= 5)
Gene RIFs: 173 (req: > 3)
Antibodies: 634 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (266)
Nearest Tclin Targets (3)
Upstream (2)
Downstream (1)
1 – 2 of 2
Pathways (10)
KEGG (3)
PathwayCommons (5)
WikiPathways (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Inflammatory bowel disease (IBD) | ||||
KEGG | Th17 cell differentiation | ||||
KEGG | Th1 and Th2 cell differentiation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Inflammatory bowel disease (IBD) | ||||
Th17 cell differentiation | ||||
Th1 and Th2 cell differentiation | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (5)
Components (2)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence Model (ISM) | NTNU_SB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred by Curator (IC) | NTNU_SB | |||
Disease Associations (null)
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 2 | 3 | 4 | 89.1 | |||||
total cholesterol measurement | 2 | 3 | 4 | 87.3 | |||||
serum non-albumin protein measurement | 1 | 3 | 3 | 87.3 | |||||
sex hormone-binding globulin measurement | 2 | 1 | 2 | 85.6 | |||||
pulse pressure measurement | 1 | 1 | 1 | 80.1 | |||||
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 4 | 89.1 | |||||
total cholesterol measurement | 4 | 87.3 | |||||
serum non-albumin protein measurement | 3 | 87.3 | |||||
sex hormone-binding globulin measurement | 2 | 85.6 | |||||
pulse pressure measurement | 1 | 80.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | T-box 21 | VGNC:9678 | 749275 | |||||
Macaque | T-box 21 | 694044 | ||||||
Mouse | MGI:1888984 | 57765 | ||||||
Rat | RGD:1308264 | 303496 | ||||||
Dog | T-box 21 | VGNC:47173 | 491044 | |||||
Publication Statistics
PubMed Score 1044.70
PubMed score by year
PubTator Score 366.63
PubTator score by year
Related Publications
Text Mined References (185)
GeneRif Annotations (173)
Items per page:
0 of 0
PMID | Year | Title |
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