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Tbio
TBX19
T-box transcription factor TBX19

Protein Summary
Description
Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367821
  • ENSP00000356795
  • ENSG00000143178

Symbol
  • TPIT
  • TPIT
  • TBS19
  • dJ747L4.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
cell type or tissue
0.67
biological process
0.6
protein domain
0.58
small molecule perturbation
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.99   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.99   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
POMC
Tbio
Novelty:  0.00002436
Score:  0.945
Data Source:  STRINGDB
POU1F1
Tbio
Family:  TF
Novelty:  0.0052029
Score:  0.847
Data Source:  STRINGDB
LHX3
Tbio
Family:  TF
Novelty:  0.00784158
Score:  0.814
Data Source:  STRINGDB
PITX1
Tbio
Family:  TF
Novelty:  0.00499796
Score:  0.813
Data Source:  STRINGDB
HESX1
Tbio
Family:  TF
Novelty:  0.00806405
Score:  0.803
Data Source:  STRINGDB
LHX4
Tbio
Family:  TF
Novelty:  0.02047732
Score:  0.791
Data Source:  STRINGDB
NR5A1
Tchem
Family:  NR
Novelty:  0.00126037
Score:  0.77
Data Source:  STRINGDB
PROP1
Tbio
Family:  TF
Novelty:  0.00510395
Score:  0.696
Data Source:  STRINGDB
TSHB
Tbio
Novelty:  0.00194403
Score:  0.695
Data Source:  STRINGDB
GHRHR
Tclin
Family:  GPCR
Novelty:  0.00637611
Score:  0.683
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (111)
Find Similar Targets
Items per page:
1 – 5 of 111
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Corticotropin-releasing hormone signaling pathway
WikiPathways
Corticotropin-releasing hormone signaling pathway
WikiPathways
Corticotropin-releasing hormone signaling pathway
WikiPathways
Corticotropin-releasing hormone signaling pathway
WikiPathways
Corticotropin-releasing hormone signaling pathway
Name
Explore in Pharos
Explore in Source
Corticotropin-releasing hormone signaling pathway
Corticotropin-releasing hormone signaling pathway
Corticotropin-releasing hormone signaling pathway
Corticotropin-releasing hormone signaling pathway
Corticotropin-releasing hormone signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
1
2
11.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
11.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1891158
83993
Dog
T-box 19
VGNC:47170
449029
Horse
T-box 19
VGNC:23931
100051717
Cow
T-box 19
VGNC:35665
514352
Pig
T-box 19
100151956
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
T-box 19
Horse
T-box 19
Cow
T-box 19
Pig
T-box 19
Publication Statistics
PubMed Score 70.99
PubMed score by year
PubTator Score 35.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title