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Tbio
TBRG4
FAST kinase domain-containing protein 4

Protein Summary
Description
Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression (PubMed:9383053).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258770
  • ENSP00000258770
  • ENSG00000136270
  • ENST00000361278
  • ENSP00000354992
  • ENST00000395655
  • ENSP00000379016
  • ENST00000494076
  • ENSP00000420597

Symbol
  • CPR2
  • FASTKD4
  • KIAA0948
  • CPR2
  • FASTKD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor binding site profile
0.91
histone modification site profile
0.85
kinase perturbation
0.84
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.91   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.91   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
FRRS1L
Tbio
Novelty:  0.00607449
p_int:  0.999986382
p_wrong:  0.000013618
Score:  0.277
Data Source:  BioPlex,STRINGDB
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.999931994
p_ni:  0.000068006
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
p_int:  0.99948129
p_ni:  0.00051871
Score:  0.151
Data Source:  BioPlex,STRINGDB
PNPT1
Tbio
Family:  Enzyme
Novelty:  0.00339969
p_int:  0.999277968
p_ni:  0.000722032
Score:  0.629
Data Source:  BioPlex,STRINGDB
CD70
Tbio
Novelty:  0.00420393
p_int:  0.998603907
p_ni:  0.001396093
Data Source:  BioPlex
IGSF8
Tbio
Novelty:  0.03016623
p_int:  0.998467909
p_ni:  0.001532091
Data Source:  BioPlex
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.998306212
p_ni:  0.001693788
Score:  0.253
Data Source:  BioPlex,STRINGDB
PGAP3
Tbio
Novelty:  0.01842385
p_int:  0.977309223
p_ni:  0.022690777
Score:  0.519
Data Source:  BioPlex,STRINGDB
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.955562356
p_ni:  0.044437643
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.952736306
p_ni:  0.047263694
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
53.3
platelet crit
1
1
1
30.2
eosinophil count
2
1
2
29.9
smoking status measurement
1
1
1
26.6
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
53.3
platelet crit
1
30.2
eosinophil count
2
29.9
smoking status measurement
1
26.6
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta regulator 4
VGNC:4529
472360
Macaque
transforming growth factor beta regulator 4
697717
Mouse
MGI:1100868
21379
Rat
RGD:1309737
360977
Dog
transforming growth factor beta regulator 4
VGNC:47168
482691
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta regulator 4
Macaque
transforming growth factor beta regulator 4
Mouse
Rat
Dog
transforming growth factor beta regulator 4
Publication Statistics
PubMed Score 30.91
PubMed score by year
PubTator Score 17.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title