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Tbio
TBPL2
TATA box-binding protein-like protein 2

Protein Summary
Description
Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247219
  • ENSP00000247219
  • ENSG00000182521

Symbol
  • TBP2
  • TRF3
  • TBP2
  • TRF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.58
biological process
0.53
cell type or tissue
0.5
tissue
0.47
cell line
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.56   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.56   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (153)
TAF3
Tbio
Family:  Epigenetic
Novelty:  0.05517331
Score:  0.977
Data Source:  STRINGDB
GTF2B
Tbio
Novelty:  0.00179492
Score:  0.957
Data Source:  STRINGDB
GTF2A1
Tchem
Novelty:  0.19577296
Score:  0.957
Data Source:  STRINGDB
TAF6
Tbio
Novelty:  0.04357176
Score:  0.934
Data Source:  STRINGDB
TAF12
Tbio
Novelty:  0.04352637
Score:  0.925
Data Source:  STRINGDB
TAF4
Tbio
Novelty:  0.02101584
Score:  0.914
Data Source:  STRINGDB
TAF5
Tbio
Novelty:  0.05443551
Score:  0.91
Data Source:  STRINGDB
TAF7
Tbio
Novelty:  0.05316615
Score:  0.91
Data Source:  STRINGDB
CDX4
Tbio
Family:  TF
Novelty:  0.02299021
Score:  0.906
Data Source:  STRINGDB
TAF2
Tbio
Novelty:  0.0397428
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
Pathways (7)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Human T-cell leukemia virus 1 infection
KEGG
Huntington disease
KEGG
Basal transcription factors
KEGG
Viral carcinogenesis
KEGG
Human papillomavirus infection
Name
Explore in Pharos
Explore in Source
Human T-cell leukemia virus 1 infection
Huntington disease
Basal transcription factors
Viral carcinogenesis
Human papillomavirus infection
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
galectin-3 measurement
1
2
2
96.2
mean platelet volume
2
2
2
95.4
blood protein measurement
1
1
1
87
eosinophil count
1
1
1
76.4
eosinophil percentage of leukocytes
1
1
1
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
galectin-3 measurement
2
96.2
mean platelet volume
2
95.4
blood protein measurement
1
87
eosinophil count
1
76.4
eosinophil percentage of leukocytes
1
68.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein like 2
VGNC:3306
452923
Macaque
TATA-box binding protein like 2
697371
Mouse
MGI:2684058
227606
Rat
RGD:1596837
680050
Dog
TATA-box binding protein like 2
VGNC:47165
611011
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein like 2
Macaque
TATA-box binding protein like 2
Mouse
Rat
Dog
TATA-box binding protein like 2
Publication Statistics
PubMed Score 81.56
PubMed score by year
PubTator Score 34.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title