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Tbio
TBPL1
TATA box-binding protein-like protein 1

Protein Summary
Description
Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box. This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237264
  • ENSP00000237264
  • ENSG00000028839
  • ENST00000613034
  • ENSP00000478795

Symbol
  • TLF
  • TLP
  • TLP21
  • TRF2
  • TRP
  • TLF
  • TLP
  • STUD
  • TRF2
  • MGC:8389
  • MGC:9620
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.84
transcription factor binding site profile
0.78
biological process
0.76
tissue
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.28   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.28   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (145)
GTF2A1
Tchem
Novelty:  0.19577296
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
GTF2A2
Tbio
Novelty:  0.03391028
p_int:  0.999999997
p_ni:  3e-9
Score:  0.894
Data Source:  BioPlex,STRINGDB
GTF2B
Tbio
Novelty:  0.00179492
Score:  0.971
Data Source:  STRINGDB
TAF6
Tbio
Novelty:  0.04357176
Score:  0.928
Data Source:  STRINGDB
TBPL2
Tbio
Novelty:  0.01299173
Score:  0.903
Data Source:  STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.902
Data Source:  STRINGDB
ZBED1
Tbio
Family:  TF
Novelty:  0.01645222
Score:  0.892
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.875
Data Source:  STRINGDB
BRF2
Tbio
Novelty:  0.39111125
Score:  0.87
Data Source:  STRINGDB
TAF1L
Tchem
Family:  Epigenetic
Novelty:  0.00567731
Score:  0.842
Data Source:  STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
Pathways (8)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Human T-cell leukemia virus 1 infection
KEGG
Huntington disease
KEGG
Basal transcription factors
KEGG
Viral carcinogenesis
KEGG
Human papillomavirus infection
Name
Explore in Pharos
Explore in Source
Human T-cell leukemia virus 1 infection
Huntington disease
Basal transcription factors
Viral carcinogenesis
Human papillomavirus infection
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
2
3
1.1
92.4
1
1
0
1.1
72.6
hemoglobin measurement
2
2
2
62.6
creatinine measurement
1
1
1
58.4
glomerular filtration rate
1
1
1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
92.4
0
1.1
72.6
hemoglobin measurement
2
62.6
creatinine measurement
1
58.4
glomerular filtration rate
1
57.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein like 1
VGNC:3740
463010
Mouse
MGI:1339946
237336
Rat
RGD:1597456
689030
Dog
TATA-box binding protein like 1
476209
Horse
TATA-box binding protein like 1
VGNC:23927
100067729
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein like 1
Mouse
Rat
Dog
TATA-box binding protein like 1
Horse
TATA-box binding protein like 1
Publication Statistics
PubMed Score 53.28
PubMed score by year
PubTator Score 45.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title