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Tbio
TBP
TATA-box-binding protein

Protein Summary
Description
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071). Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription (PubMed:15970593). The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Initiati ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230354
  • ENSP00000230354
  • ENSG00000112592
  • ENST00000392092
  • ENSP00000375942
  • ENST00000540980
  • ENSP00000442132

Symbol
  • GTF2D1
  • TF2D
  • TFIID
  • HDL4
  • GTF2D
  • SCA17
  • TFIID
  • GTF2D1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
viral protein
1
virus
1
hub protein
0.99
cellular component
0.93
transcription factor binding site profile
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3387.94   (req: < 5)
Gene RIFs: 89   (req: <= 3)
Antibodies: 541   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3387.94   (req: >= 5)
Gene RIFs: 89   (req: > 3)
Antibodies: 541   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (475)
GTF2A1
Tchem
Novelty:  0.19577296
p_int:  0.995982218
p_ni:  0.004017782
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
LRRC46
Tdark
Novelty:  1.159245
p_int:  0.988609046
p_ni:  0.011390954
Score:  0.194
Data Source:  BioPlex,STRINGDB
CUEDC2
Tbio
Novelty:  0.07403123
p_int:  0.973702691
p_ni:  0.026297309
Score:  0.871
Data Source:  BioPlex,STRINGDB
SPATA25
Tbio
Novelty:  0.80142563
p_int:  0.937385824
p_ni:  0.062614176
Data Source:  BioPlex
NFKBIB
Tbio
Novelty:  0.00517222
p_int:  0.918184482
p_ni:  0.081815518
Score:  0.28
Data Source:  BioPlex,STRINGDB
TAF12
Tbio
Novelty:  0.04352637
Score:  0.999
Data Source:  STRINGDB
TAF10
Tbio
Novelty:  0.0276004
Score:  0.999
Data Source:  STRINGDB
GTF2B
Tbio
Novelty:  0.00179492
Score:  0.999
Data Source:  STRINGDB
TAF4
Tbio
Novelty:  0.02101584
Score:  0.999
Data Source:  STRINGDB
AK6
Tbio
Family:  Kinase
Novelty:  0.173427
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
Pathways (55)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 41
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Disease
Reactome
ESR-mediated signaling
Reactome
Epigenetic regulation of gene expression
Reactome
Estrogen-dependent gene expression
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Disease
ESR-mediated signaling
Epigenetic regulation of gene expression
Estrogen-dependent gene expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
Find Similar Targets
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein
VGNC:3726
738472
Macaque
TATA-box binding protein
696258
Mouse
MGI:101838
21374
Rat
RGD:67398
117526
Dog
TATA-box binding protein
VGNC:47164
611193
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein
Macaque
TATA-box binding protein
Mouse
Rat
Dog
TATA-box binding protein
Publication Statistics
PubMed Score 3387.94
PubMed score by year
PubTator Score 1269.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title