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Tbio
TBL1Y
F-box-like/WD repeat-containing protein TBL1Y

Protein Summary
Description
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity). The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene is highly similar to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346432
  • ENSP00000328879
  • ENSG00000092377
  • ENST00000355162
  • ENSP00000347289
  • ENST00000383032
  • ENSP00000372499

Symbol
  • TBL1
  • TBL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.62
small molecule perturbation
0.51
protein complex
0.41
tissue
0.4


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
TBL1X
Tbio
Novelty:  0.00027212
p_int:  0.999999991
p_ni:  9e-9
Data Source:  BioPlex
NCOR2
Tchem
Family:  TF
Novelty:  0.00066449
p_int:  0.999999989
p_ni:  1.1e-8
Data Source:  BioPlex
TBL1XR1
Tbio
Novelty:  0.00503043
p_int:  0.99999941
p_ni:  5.9e-7
Data Source:  BioPlex
GPS2
Tbio
Novelty:  0.00986158
p_int:  0.999999109
p_ni:  7e-9
p_wrong:  8.84e-7
Data Source:  BioPlex
NCOR1
Tchem
Family:  TF
Novelty:  0.0021926
p_int:  0.999997922
p_ni:  0.000002078
Data Source:  BioPlex
HDAC3
Tclin
Family:  Epigenetic
Novelty:  0.00393172
p_int:  0.999980819
p_ni:  0.000019181
Data Source:  BioPlex
CAPN15
Tbio
Novelty:  0.01046841
p_int:  0.999441635
p_ni:  0.000558358
p_wrong:  7e-9
Data Source:  BioPlex
INTS6
Tbio
Novelty:  0.02680242
p_int:  0.997989904
p_ni:  0.00201008
p_wrong:  1.6e-8
Data Source:  BioPlex
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
p_int:  0.991261126
p_ni:  0.008738852
p_wrong:  2.2e-8
Data Source:  BioPlex
LRIF1
Tdark
Novelty:  0.26861958
p_int:  0.982539129
p_ni:  0.017460871
Data Source:  BioPlex
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
24.6
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
24.6
21.5
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubTator Score 25.95
PubTator score by year
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Related Publications
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PMID
Year
Title