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Tbio
TBKBP1
TANK-binding kinase 1-binding protein 1

Protein Summary
Description
Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361722
  • ENSP00000354777
  • ENSG00000198933
  • ENST00000622396
  • ENSP00000484395

Symbol
  • KIAA0775
  • SINTBAD
  • SINTBAD
  • ProSAPiP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.83
transcription factor
0.7
histone modification site profile
0.68
cell line
0.59
small molecule perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.28   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.28   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999999814
p_ni:  1.86e-7
Data Source:  BioPlex
DPPA3
Tbio
Novelty:  0.03361743
p_int:  0.999989585
p_ni:  0.000010351
p_wrong:  6.4e-8
Data Source:  BioPlex
CALCOCO2
Tbio
Novelty:  0.01456844
p_int:  0.999985167
p_ni:  0.000012386
p_wrong:  0.000002447
Score:  0.919
Data Source:  BioPlex,STRINGDB
TANK
Tbio
Novelty:  0.01003866
Score:  0.939
Data Source:  STRINGDB
TBK1
Tchem
Family:  Kinase
Novelty:  0.00194753
Score:  0.908
Data Source:  STRINGDB
AZI2
Tbio
Novelty:  0.23255317
Score:  0.901
Data Source:  STRINGDB
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
Score:  0.885
Data Source:  STRINGDB
AGO2
Tbio
Novelty:  0.00057003
Score:  0.82
Data Source:  STRINGDB
IKBKE
Tchem
Family:  Kinase
Novelty:  0.01447079
Score:  0.751
Data Source:  STRINGDB
PNPO
Tchem
Family:  Enzyme
Novelty:  0.00919993
Score:  0.714
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
3
4
89.1
total cholesterol measurement
2
3
4
87.3
serum non-albumin protein measurement
1
3
3
87.3
sex hormone-binding globulin measurement
2
1
2
85.6
pulse pressure measurement
1
1
1
80.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
89.1
total cholesterol measurement
4
87.3
serum non-albumin protein measurement
3
87.3
sex hormone-binding globulin measurement
2
85.6
pulse pressure measurement
1
80.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBK1 binding protein 1
VGNC:12721
455177
Macaque
TBK1 binding protein 1
693913
Mouse
MGI:1920424
73174
Rat
RGD:631328
266764
Dog
TBK1 binding protein 1
VGNC:47161
491043
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBK1 binding protein 1
Macaque
TBK1 binding protein 1
Mouse
Rat
Dog
TBK1 binding protein 1
Publication Statistics
PubMed Score 7.28
PubMed score by year
PubTator Score 5.14
PubTator score by year
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Related Publications
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PMID
Year
Title