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Tbio
TBKBP1
TANK-binding kinase 1-binding protein 1

Protein Summary
Description
Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361722
  • ENSP00000354777
  • ENSG00000198933
  • ENST00000622396
  • ENSP00000484395

Symbol
  • KIAA0775
  • SINTBAD
  • SINTBAD
  • ProSAPiP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.83
transcription factor
0.7
histone modification site profile
0.68
cell line
0.59
small molecule perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.29   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.29   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0