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Tchem
TBK1
Serine/threonine-protein kinase TBK1

Protein Summary
Description
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331710
  • ENSP00000329967
  • ENSG00000183735

Symbol
  • NAK
  • NAK
  • T2K
  • IIAE8
  • FTDALS4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
disease perturbation
0.99
biological process
0.95
molecular function
0.94
histone modification site profile
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 762.15   (req: < 5)
Gene RIFs: 150   (req: <= 3)
Antibodies: 571   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 762.15   (req: >= 5)
Gene RIFs: 150   (req: > 3)
Antibodies: 571   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 118
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2