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Tbio
TBCD
Tubulin-specific chaperone D

Protein Summary
Description
Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed:10722852, PubMed:10831612, PubMed:11847227, PubMed:20740604, PubMed:27666370, PubMed:28158450). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed:27666370). Involved in neuron morphogenesis (PubMed:27666374). Cofactor D is one o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355528
  • ENSP00000347719
  • ENSG00000141556

Symbol
  • KIAA0988
  • SSD1
  • TFCD
  • tfcD
  • PEBAT
  • SSD-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
transcription factor binding site profile
0.76
disease perturbation
0.74
kinase perturbation
0.71
cell line
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.15   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.15   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (123)
ARL2
Tbio
Family:  Enzyme
Novelty:  0.01989908
p_int:  0.999992045
p_ni:  0.000007955
Score:  0.997
Data Source:  BioPlex,STRINGDB
TUBB
Tclin
Novelty:  0.0038007
p_int:  0.999939842
p_ni:  0.000060158
Score:  0.811
Data Source:  BioPlex,STRINGDB
TUBB2B
Tclin
Novelty:  0.02905844
p_int:  0.999834458
p_ni:  0.000165542
Score:  0.961
Data Source:  BioPlex,STRINGDB
TUBB2A
Tclin
Novelty:  0.00902924
p_int:  0.999534936
p_ni:  0.000465064
Score:  0.986
Data Source:  BioPlex,STRINGDB
LRRC4
Tbio
Novelty:  0.03600857
p_int:  0.99089044
p_ni:  0.00910956
Score:  0.175
Data Source:  BioPlex,STRINGDB
BSG
Tbio
Novelty:  0.0010285
p_int:  0.989215773
p_ni:  0.010784227
Data Source:  BioPlex
NCR3LG1
Tbio
Novelty:  0.02681936
p_int:  0.984260312
p_ni:  0.015739688
Data Source:  BioPlex
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.923968564
p_ni:  0.076031436
Data Source:  BioPlex
CRYL1
Tbio
Family:  Enzyme
Novelty:  0.04513297
p_int:  0.923124607
p_ni:  0.076875393
Data Source:  BioPlex
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.914189816
p_ni:  0.085810184
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-chaperonin tubulin folding pathway
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-chaperonin tubulin folding pathway
Protein folding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
13
19
24
99.6
heel bone mineral density
1
1
1
70.5
red blood cell distribution width
1
1
1
58.4
neutrophil percentage of leukocytes
1
1
1
46.9
hair color
1
1
0
1.1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
24
99.6
heel bone mineral density
1
70.5
red blood cell distribution width
1
58.4
neutrophil percentage of leukocytes
1
46.9
hair color
0
1.1
45.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin folding cofactor D
VGNC:9676
455000
Macaque
tubulin folding cofactor D
719682
Mouse
MGI:1919686
108903
Rat
RGD:2320148
100361417
Dog
tubulin folding cofactor D
VGNC:47156
491683
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin folding cofactor D
Macaque
tubulin folding cofactor D
Mouse
Rat
Dog
tubulin folding cofactor D
Publication Statistics
PubMed Score 87.15
PubMed score by year
PubTator Score 38.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title