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Tbio
TBCCD1
TBCC domain-containing protein 1

Protein Summary
Description
Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338733
  • ENSP00000341652
  • ENSG00000113838
  • ENST00000424280
  • ENSP00000411253
  • ENST00000446782
  • ENSP00000397091
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
protein domain
0.73
cell type or tissue
0.67
gene perturbation
0.59
tissue sample
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.45   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.45   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  1
Score:  0.663
Data Source:  BioPlex,STRINGDB
PPP2R3B
Tbio
Family:  Enzyme
Novelty:  0.02932064
p_int:  0.999999996
p_ni:  3e-9
p_wrong:  1e-9
Score:  0.811
Data Source:  BioPlex,STRINGDB
KRBA1
Tdark
Novelty:  2.59384945
p_int:  0.999988553
p_ni:  0.000011228
p_wrong:  2.2e-7
Score:  0.588
Data Source:  BioPlex,STRINGDB
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.999976475
p_ni:  0.000023525
Data Source:  BioPlex
RNF10
Tbio
Novelty:  0.09086567
p_int:  0.99995036
p_ni:  0.000041839
p_wrong:  0.000007801
Data Source:  BioPlex
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.999920519
p_ni:  0.000079481
Data Source:  BioPlex
FAM13A
Tbio
Novelty:  0.02851485
p_int:  0.999893475
p_ni:  0.0000158
p_wrong:  0.000090725
Score:  0.297
Data Source:  BioPlex,STRINGDB
CCDC9
Tdark
Novelty:  0.73149492
p_int:  0.999875436
p_ni:  0.000121672
p_wrong:  0.000002891
Data Source:  BioPlex
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
p_int:  0.999833268
p_ni:  0.000166732
Data Source:  BioPlex
PPP2R1B
Tbio
Family:  Enzyme
Novelty:  0.03936638
p_int:  0.998319443
p_ni:  0.001680557
Score:  0.219
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
3
3
77.2
intraocular pressure measurement
1
1
1
61.4
electrocardiography
1
1
5
21.5
neutrophil count
1
1
1
6.3
illegal drug consumption
1
1
0
15.7
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
3
77.2
intraocular pressure measurement
1
61.4
electrocardiography
5
21.5
neutrophil count
1
6.3
illegal drug consumption
0
15.7
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBCC domain containing 1
VGNC:2599
460910
Macaque
TBCC domain containing 1
700153
Mouse
MGI:1917823
70573
Rat
RGD:1309604
303830
Dog
TBCC domain containing 1
VGNC:47155
488117
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBCC domain containing 1
Macaque
TBCC domain containing 1
Mouse
Rat
Dog
TBCC domain containing 1
Publication Statistics
PubMed Score 5.45
PubMed score by year
PubTator Score 1.50
PubTator score by year
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Related Publications
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PMID
Year
Title