Tbio TBCB Tubulin-folding cofactor B

Protein Summary

Description

Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity).

Uniprot Accession IDs

• Q99426
• O00111
• O00674
• O14728
• Q6FGY5

Gene Name

• TBCB

Ensembl ID

• ENST00000221855
• ENSP00000221855
• ENSG00000105254
• ENST00000585746
• ENSP00000467487

Symbol

• CG22
• CKAP1
• CG22
• CKAP1
• CKAPI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.99
histone modification site profile	0.89
virus perturbation	0.79
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Chaperone / Tubulin-folding Cofactor B

DTO Classes

Protein / Chaperone / Tubulin-folding Cofactor B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.9   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 263   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.9   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0