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Tbio
TBCA
Tubulin-specific chaperone A

Protein Summary
Description
Tubulin-folding protein; involved in the early step of the tubulin folding pathway. The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306388
  • ENSP00000306362
  • ENSG00000171530
  • ENST00000380377
  • ENSP00000369736
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
tissue sample
0.69
disease perturbation
0.68
transcription factor binding site profile
0.68
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.25   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.25   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
MICAL1
Tbio
Family:  Enzyme
Novelty:  0.02668048
p_int:  0.997747598
p_ni:  0.002252129
p_wrong:  2.73e-7
Data Source:  BioPlex
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.944135845
p_ni:  0.055672931
p_wrong:  0.000191224
Data Source:  BioPlex
GNAZ
Tbio
Novelty:  0.02008523
p_int:  0.766652083
p_ni:  0.05003937
p_wrong:  0.183308547
Data Source:  BioPlex
TBCE
Tbio
Novelty:  0.01058281
Score:  0.995
Data Source:  STRINGDB
TBCD
Tbio
Novelty:  0.01161221
Score:  0.99
Data Source:  Reactome,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
Score:  0.983
Data Source:  STRINGDB
TUBB2A
Tclin
Novelty:  0.00902924
Score:  0.982
Data Source:  STRINGDB
TUBB2B
Tclin
Novelty:  0.02905844
Score:  0.959
Data Source:  STRINGDB
TUBB4A
Tclin
Novelty:  0.00045092
Score:  0.958
Data Source:  STRINGDB
TUBB4B
Tclin
Novelty:  0.04120134
Score:  0.957
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-chaperonin tubulin folding pathway
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-chaperonin tubulin folding pathway
Protein folding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
3
3
82.1
electrocardiography
1
1
3
24.5
age at first sexual intercourse measurement
1
1
1
17.8
platelet count
1
1
1
14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
82.1
electrocardiography
3
24.5
age at first sexual intercourse measurement
1
17.8
platelet count
1
14
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin folding cofactor A
VGNC:4189
737862
Mouse
MGI:107549
21371
Rat
RGD:1311538
366995
Dog
tubulin folding cofactor A
VGNC:53246
479173
Horse
tubulin folding cofactor A [Source:HGNC Symbol;Acc:HGNC:11579]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin folding cofactor A
Mouse
Rat
Dog
tubulin folding cofactor A
Horse
tubulin folding cofactor A [Source:HGNC Symbol;Acc:HGNC:11579]
Publication Statistics
PubMed Score 14.25
PubMed score by year
PubTator Score 38.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title