You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TBC1D9B
TBC1 domain family member 9B

Protein Summary
Description
May act as a GTPase-activating protein for Rab family protein(s).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355235
  • ENSP00000347375
  • ENSG00000197226
  • ENST00000356834
  • ENSP00000349291
  • ENST00000639361
  • ENSP00000491970
  • ENSG00000284400
  • ENST00000639711
  • ENSP00000491373

Symbol
  • KIAA0676
  • GRAMD9B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
virus perturbation
0.92
transcription factor perturbation
0.91
histone modification site profile
0.81
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.95   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.95   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
CTAG2
Tbio
Novelty:  0.02983879
p_int:  0.999981446
p_ni:  0.000018549
p_wrong:  5e-9
Data Source:  BioPlex
TBC1D9
Tbio
Novelty:  0.20059899
p_int:  0.999923197
p_ni:  0.000076803
Score:  0.573
Data Source:  BioPlex,STRINGDB
ALDH3A2
Tbio
Family:  Enzyme
Novelty:  0.0059198
p_int:  0.999563017
p_ni:  0.000436983
Data Source:  BioPlex
ADORA3
Tchem
Family:  GPCR
Novelty:  0.00089511
p_int:  0.99930851
p_ni:  0.00069149
Score:  0.227
Data Source:  BioPlex,STRINGDB
LANCL1
Tbio
Novelty:  0.06479031
p_int:  0.998703265
p_ni:  0.001296735
Score:  0.558
Data Source:  BioPlex,STRINGDB
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.99724064
p_ni:  0.002759112
p_wrong:  2.49e-7
Data Source:  BioPlex
PIP4P1
Tbio
Family:  Enzyme
Novelty:  0.23320432
p_int:  0.995753932
p_ni:  0.004246068
Score:  0.328
Data Source:  BioPlex,STRINGDB
ARL8A
Tbio
Family:  Enzyme
Novelty:  0.12499089
p_int:  0.99574261
p_ni:  0.004257374
p_wrong:  1.6e-8
Score:  0.199
Data Source:  BioPlex,STRINGDB
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.995282655
p_ni:  0.004717344
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.990144594
p_ni:  0.009855404
p_wrong:  3e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
82.3
monocyte percentage of leukocytes
2
2
2
82.3
neutrophil count
2
2
2
81.4
neutrophil count
2
2
2
81.4
monocyte count
1
1
1
73.2
Items per page:
1 – 5 of 20
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
82.3
monocyte percentage of leukocytes
2
82.3
neutrophil count
2
81.4
neutrophil count
2
81.4
monocyte count
1
73.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TBC1 domain family member 9B
715258
Mouse
MGI:1924045
76795
Rat
RGD:1310147
360520
Dog
TBC1 domain family member 9B
VGNC:47153
481460
Horse
TBC1 domain family member 9B
VGNC:23915
100067181
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TBC1 domain family member 9B
Mouse
Rat
Dog
TBC1 domain family member 9B
Horse
TBC1 domain family member 9B
Publication Statistics
PubMed Score 1.95
PubMed score by year
PubTator Score 0.17
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title