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Tbio
TBC1D9
TBC1 domain family member 9

Protein Summary
Description
May act as a GTPase-activating protein for Rab family protein(s).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000442267
  • ENSP00000411197
  • ENSG00000109436

Symbol
  • KIAA0882
  • TBC1D9A
  • MDR1
  • GRAMD9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
virus perturbation
0.88
microRNA
0.8
transcription factor binding site profile
0.8
histone modification site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.61   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.61   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
ABHD16A
Tchem
Family:  Enzyme
Novelty:  0.04797219
p_int:  0.999997207
p_ni:  0.000002793
Score:  0.208
Data Source:  BioPlex,STRINGDB
TBC1D9B
Tdark
Novelty:  0.66719861
p_int:  0.999923197
p_ni:  0.000076803
Score:  0.573
Data Source:  BioPlex,STRINGDB
CTAG2
Tbio
Novelty:  0.02983879
p_int:  0.999900636
p_ni:  0.000099338
p_wrong:  2.6e-8
Data Source:  BioPlex
PIP4P2
Tbio
Family:  Enzyme
Novelty:  0.94294105
p_int:  0.999705407
p_ni:  0.000055304
p_wrong:  0.000239289
Score:  0.228
Data Source:  BioPlex,STRINGDB
LANCL1
Tbio
Novelty:  0.06479031
p_int:  0.99891006
p_ni:  0.001089765
p_wrong:  1.75e-7
Score:  0.692
Data Source:  BioPlex,STRINGDB
MRS2
Tbio
Novelty:  0.00264753
p_int:  0.987964957
p_ni:  0.012035043
Score:  0.16
Data Source:  BioPlex,STRINGDB
CPT1A
Tchem
Family:  Enzyme
Novelty:  0.00281783
p_int:  0.986565908
p_ni:  0.013434092
Score:  0.252
Data Source:  BioPlex,STRINGDB
ARL8A
Tbio
Family:  Enzyme
Novelty:  0.12499089
p_int:  0.964812301
p_ni:  0.024502918
p_wrong:  0.010684781
Score:  0.208
Data Source:  BioPlex,STRINGDB
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.942818886
p_ni:  0.056523537
p_wrong:  0.000657577
Data Source:  BioPlex
MUL1
Tbio
Family:  Enzyme
Novelty:  0.00841786
p_int:  0.779572368
p_ni:  0.220427597
p_wrong:  3.5e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.8
21.5
1
1
0
5.9
6.4
age at onset
1
1
0
5.9
6.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.8
21.5
0
5.9
6.4
age at onset
0
5.9
6.4
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 9
VGNC:2960
738339
Macaque
TBC1 domain family member 9
702230
Mouse
MGI:1918560
71310
Rat
RGD:1308221
304645
Horse
TBC1 domain family member 9
VGNC:23914
100071321
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 9
Macaque
TBC1 domain family member 9
Mouse
Rat
Horse
TBC1 domain family member 9
Publication Statistics
PubMed Score 4.61
PubMed score by year
PubTator Score 4.99
PubTator score by year
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Related Publications
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PMID
Year
Title