TBC1D8B
TBC1 domain family member 8B
Protein Summary
May act as a GTPase-activating protein for Rab family protein(s). This gene encodes a protein with a TBC (Tre-2/Bub2/CDC16) domain. Some mammalian proteins with this domain have been shown to function as Rab-GAPs by binding to specific Rab proteins and affecting their GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
- ENST00000310452
- ENSP00000310675
- ENSG00000133138
- ENST00000357242
- ENSP00000349781
- GRAMD8B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.86 | ||
microRNA | 0.75 | ||
transcription factor perturbation | 0.61 | ||
protein domain | 0.58 | ||
gene perturbation | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.31 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 28 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.31 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 28 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0