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Tbio
TBC1D5
TBC1 domain family member 5

Protein Summary
Description
May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253692
  • ENSP00000253692
  • ENSG00000131374
  • ENST00000429383
  • ENSP00000398127
  • ENST00000446818
  • ENSP00000402935

Symbol
  • KIAA0210
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
disease perturbation
0.83
transcription factor
0.8
transcription factor perturbation
0.74
histone modification site profile
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.89   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.89   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
VPS29
Tbio
Novelty:  0.01335106
p_int:  0.999999998
p_ni:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
VPS26A
Tbio
Novelty:  0.01804654
p_int:  0.999999991
p_ni:  9e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
VPS26B
Tdark
Novelty:  0.25702869
p_int:  0.999999991
p_ni:  8e-9
Score:  0.986
Data Source:  BioPlex,STRINGDB
LRRC73
Tdark
Novelty:  48
p_int:  0.999999956
p_ni:  4.4e-8
Data Source:  BioPlex
MFAP4
Tbio
Novelty:  0.02023782
p_int:  0.999999446
p_ni:  5.54e-7
Data Source:  BioPlex
VPS35
Tbio
Novelty:  0.00729892
Score:  0.968
Data Source:  STRINGDB
SNX1
Tbio
Novelty:  0.01267973
Score:  0.962
Data Source:  STRINGDB
SNX2
Tbio
Novelty:  0.03880384
Score:  0.96
Data Source:  STRINGDB
SNX5
Tbio
Novelty:  0.04075649
Score:  0.95
Data Source:  STRINGDB
SNX6
Tbio
Novelty:  0.05909848
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
2
3
2.8
95.1
mean platelet volume
3
2
3
84.2
platelet crit
2
2
2
81.1
functional brain measurement
1
1
0
8.1
80.7
language measurement
1
1
0
8.1
80.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
2.8
95.1
mean platelet volume
3
84.2
platelet crit
2
81.1
functional brain measurement
0
8.1
80.7
language measurement
0
8.1
80.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 5
VGNC:7130
470764
Macaque
TBC1 domain family member 5
696122
Mouse
MGI:1919488
72238
Rat
RGD:1561626
501088
Dog
TBC1 domain family member 5
VGNC:47150
485651
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 5
Macaque
TBC1 domain family member 5
Mouse
Rat
Dog
TBC1 domain family member 5
Publication Statistics
PubMed Score 10.89
PubMed score by year
PubTator Score 2.87
PubTator score by year
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Related Publications
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PMID
Year
Title